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A novel synthetic melanin as a potential anticancer agent that induces apoptosis and cyclin D downregulation through distinct pathways. [PDF]
J Biol ChemKawamoto Y +16 more
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International Journal of Biochemistry and Cell Biology, 1997
Melanin is an irregular light-absorbing polymer containing indoles and other intermediate products derived from the oxidation of tyrosine. Melanin is widely dispersed in the animal and plant kingdoms. It is the major pigment present in the surface structures of vertebrates.
P A Riley, P A Riley
exaly +3 more sources
Melanin is an irregular light-absorbing polymer containing indoles and other intermediate products derived from the oxidation of tyrosine. Melanin is widely dispersed in the animal and plant kingdoms. It is the major pigment present in the surface structures of vertebrates.
P A Riley, P A Riley
exaly +3 more sources
Binding of Memantine to Melanin: Influence of Type of Melanin and Characteristics [PDF]
Pharmaceutical Research, 2003 The objectives of this study were to characterize sepia, synthetic, and bovine melanin and to determine their binding characteristics to the drug memantine.Physical methods were used to characterize sepia, synthetic, and bovine melanin. Their binding properties toward memantine were determined in deionized water and phosphate-buffered saline (PBS) at ...
Koeberle, M. +3 more
openaire +5 more sources
Melanin-like Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration [PDF]
ACS Nano, 2022 Melanin is a natural pigment that is widely distributed in many parts of the human body, such as the skin and retinal pigment epithelium (RPE) in eyes.
Yong-Su Kwon, Zongchao Han
exaly +2 more sources
Nature, 1964
AQUEOUS systems were reported earlier in which a manganese-phenothiazine auto-oxidation led to the emergence of semiquinone free-radicals of the drugs1. The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these agents2.
G C, COTZIAS +2 more
openaire +2 more sources
AQUEOUS systems were reported earlier in which a manganese-phenothiazine auto-oxidation led to the emergence of semiquinone free-radicals of the drugs1. The mildness of the required conditions permitted the postulation that this interaction might be relevant to the pharmacological action of these agents2.
G C, COTZIAS +2 more
openaire +2 more sources
Loss of melanin from human RPE with aging: possible role of melanin photooxidation [PDF]
Experimental Eye Research, 2003 The pigment melanin, which is believed to play a photoprotective role, was quantified here in human RPE cells from donors of different age. Electron spin resonance (ESR) spectroscopy was shown to provide a quantitative measure of melanin and was used as ...
Tadeusz Sarna +2 more
exaly +2 more sources
Current Opinion in Infectious Diseases, 2003
Production of melanin has been associated with virulence in diverse microorganisms. Melanization of fungi has been noted for many years in predominantly subcutaneous infections such as chromoblastomycosis and more recently most extensively studied in a yeast causing systemic infection, Cryptococcus neoformans. Pigmented fungi are increasingly important
Beatriz L, Gómez, Joshua D, Nosanchuk
openaire +2 more sources
Production of melanin has been associated with virulence in diverse microorganisms. Melanization of fungi has been noted for many years in predominantly subcutaneous infections such as chromoblastomycosis and more recently most extensively studied in a yeast causing systemic infection, Cryptococcus neoformans. Pigmented fungi are increasingly important
Beatriz L, Gómez, Joshua D, Nosanchuk
openaire +2 more sources