Results 51 to 60 of about 6,853 (289)

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Melaninas quimicamente modificadas: preparação, caracterização, citotoxicidade, atividade antioxidante e interação com espécies catiônicas [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015.Melaninas são bio-oligômeros de ocorrência natural que podem ser encontradas na pele, no cabelo,
Costa, Thiago Guimarães
core  

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Anti-ultraviolet, antibacterial, and biofilm eradication activities against Cutibacterium acnes of melanins and melanin derivatives from Daedaleopsis tricolor and Fomes fomentarius

Frontiers in Microbiology
Fomes fomentarius and Daedaleopsis tricolor produced significant amounts of water-insoluble melanins, and our previous study successfully enhanced their water solubility by arginine modification.
Tu N. Le, Ngan T. H. Tran, Vy N. T. Pham, Ngoc-Dung Van-Thi, Hanh T. M. Tran, Hanh T. M. Tran   +5 more
doaj   +1 more source

Comparative Biophysical and Ultrastructural Analysis of Melanins Produced by Clinical Strains of Different Species From the Trichosporonaceae Family

Frontiers in Microbiology, 2022
Melanin is one of the most studied virulence factors in pathogenic fungi. This pigment protects them from a series of both environmental and host stressors.
Iara Bastos de Andrade, Iara Bastos de Andrade, Glauber Ribeiro de Sousa Araújo, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Rosely Maria Zancopé-Oliveira, Susana Frases, Susana Frases, Rodrigo Almeida-Paes, Rodrigo Almeida-Paes   +9 more
doaj   +1 more source

METAL REDUCTION REACTIONS OF THE MELANINS: HISTOCHEMICAL STUDIES

, 1957
In general the melanins are argentaffin and, except in hair cortex, reduce ferric ferricyanide. Cutaneous and ocular melanins reduce acid silver nitrate, more promptly in guinea pigs than in man and rhesus monkeys.
R. D. LILLIE
core   +1 more source

Properties, various functions and application of bacterial melanins – some properties and possible application of melanin produced by Azotobacter chroococcum

, 2023
Melanins are a group of macromolecular pigments formed as a result of oxidative polymerization of phenolic and indole compounds. They are considered the most common, heterogeneous, resistant and evolutionarily oldest pigments found in nature.
Kozieł, Monika
core   +1 more source

Beyond Molecular Determinism: State‐Convergent Polymerization as a Functional Design Principle Under Chemical Complexity

Advanced Science, EarlyView.
This work introduces state‐convergent polymerization (SCP), a polymerization framework in which chemically diverse reaction pathways converge toward a reproducible functional polymeric state rather than a defined molecular structure. Using melanin and polydopamine as exemplars, SCP explains how robust polymer functions emerge under chemical and ...
Seonki Hong
wiley   +1 more source

Raman Characterization of Fungal DHN and DOPA Melanin Biosynthesis Pathways

Journal of Fungi, 2021
Fungal melanins represent a resource for important breakthroughs in industry and medicine, but the characterization of their composition, synthesis, and structure is not well understood.
Benjamin D. Strycker, Zehua Han, Aysan Bahari, Tuyetnhu Pham, Xiaorong Lin, Brian D. Shaw, Alexei V. Sokolov, Marlan O. Scully   +7 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source