Results 161 to 170 of about 59,513 (188)

The genetic epidemiology of melanocortin 4 receptor variants

European Journal of Pharmacology, 2011
While rare MC4R mutations are the commonest cause of monogenic forms of extreme, early-onset obesity, growing evidence shows that common MC4R variants contribute to obesity in the general population. Candidate gene studies have focussed on the V103I and I251L MC4R variants that both affect MC(4) receptor function in vitro.
openaire   +2 more sources

Melanocortin 4 receptors interact with antimicrobial frog peptide analogues

Biochemical and Biophysical Research Communications, 2006
We have developed fluorescence polarization (FP) assays of human melanocortin 4 receptor (MC4R) in 384-well microtiter plates using TAMRA-NDP-MSH as a tracer. The rank order of potency of agonists and antagonists agrees well relative to the published assays: SHU9119>MTII>NDP alphaMSH>alphaMSH.
Ernest U, Do, Eun Bae, Jo, Gyu, Choi, Long Zhu, Piao, Jaekyoon, Shin, Min-Duk, Seo, Su-Jin, Kang, Bong-Jin, Lee, Kang Ho, Kim, Jae Bum, Kim, Su-il, Kim   +10 more
openaire   +2 more sources

N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists

Journal of Medicinal Chemistry
The melanocortin receptors are a class of centrally and peripherally expressed G protein-coupled receptors, of which the MC3R and MC4R subtypes are implicated in the regulation of appetite and energy homeostasis and can serve as potential therapeutic targets for disorders such as obesity and cachexia.
Nicholas A. Weirath, Jonathan W. P. Zajac, Haley M. Donow, Travis M. Lavoi, Clemencia Pinilla, Radleigh G. Santos, Ritu Prajapati, Robert Speth, Mark D. Ericson, Sapna Sarupria, Marcello A. Giulianotti, Carrie Haskell-Luevano   +11 more
openaire   +2 more sources

Melanocortin-4 Receptor in Energy Homeostasis and Obesity Pathogenesis

2013
The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 nonsynonymous, nonsense, deletion, and frameshift MC4R mutations have been described. Vast numbers of these mutations were identified in (extremely) obese individuals. Total or partial loss
Hinney, Anke, Volckmar, Anna-Lena, Knoll, Nadja   +2 more
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

[Obesity caused by melanocortin-4 receptor mutations].

Nederlands tijdschrift voor geneeskunde, 2012
Obesity is usually the result of a combination of genetic and lifestyle factors. In monogenic obesity, overweight is caused by a single gene mutation. The most frequent form of monogenic obesity is caused by mutations in the gene that codes for the melanocortin-4 receptor (MC4R gene).
Linda, van den Berg, Miriam, Glorie-Docter, Erica, van den Akker, Henriette A, Delemarre-van de Waal   +3 more
openaire   +1 more source

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Victoria Metaxa   +2 more
exaly