Results 91 to 100 of about 412,755 (166)

Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms

Molecular Metabolism
Objectives: Carriers of PAM (peptidylglycine alpha-amidating monooxygenase) coding variant alleles have reduced insulinogenic index, higher risk of developing type 2 diabetes (T2D), and islets from heterozygous carriers of the PAM p.Asp563Gly variant ...
Yi-Chun Chen, Nils E. Bäck, Jenicia Zhen, Lena Xiong, Mitsuhiro Komba, Anna L. Gloyn, Patrick E. MacDonald, Richard E. Mains, Betty A. Eipper, C. Bruce Verchere   +9 more
doaj   +1 more source

Bio‐guided fractionation of (9Z )‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7735-7746, October 2026.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

Clinical and Genetic Profile of One Molecularly Confirmed and One Clinically Suspected Case of LZTR1 ‐Related Noonan Syndrome

Clinical Genetics, Volume 110, Issue 4, Page 502-507, October 2026.
This study illustrates the phenotypic variability of LZTR1‐related Noonan syndrome type 10 in two pediatric patients, including presentations without congenital heart defects. The findings emphasize the importance of whole‐exome sequencing and longitudinal re‐evaluation of variants of uncertain significance in achieving accurate diagnosis.
Karolina Skrzyńska, Barbara Kalina‐Faska, Ewa Błaszczyk, Aneta Gawlik‐Starzyk   +3 more
wiley   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Hypothalamic regulatory hormones

, 1973
The molecular structures of several polypeptides isolated from hypothalamic tissue have been established and the synthesis of these compounds has been achieved.
Arimura, A, Kastin, A J, Schally, A V
core   +1 more source

Passive and active avoidance responses at two levels of shock after administration of melanocyte-stimulating hormone

, 1972
Rats receiving either melanocyte-stimulating hormone (MSH) or control solution were tested in a combined active and passive avoidance task involving different visual cues and two levels of shock.
Nockton, Ransom, Kastin, Abba J, Schally, Andrew V, Elder, S.Thomas   +3 more
core   +1 more source

Alpha-melanocyte-stimulating hormone is present in the inferior petrosal sinuses in patients with Cushing's disease.

, 1993
Plasma ACTH, beta-endorphin and alpha-melanocyte-stimulating hormone levels were evaluated in the inferior petrosal sinuses and in the periphery of 22 patients affected by Cushing's disease, 11 patients with other pituitary diseases subjected to ...
CATALDI, MAURO, COLAO, ANNAMARIA, G. La Tessa, C. Oliver, MEROLA, BARTOLOMEO, DI RENZO, GIANFRANCO MARIA LUIGI, ANNUNZIATO, LUCIO, LOMBARDI, GAETANO, F. Boudouresque   +8 more
core   +1 more source

Electroencephalographic measures of melanocyte-stimulating hormone activity

, 1971
Studied EEG changes in 28 male albino rats after injections of melanocyte-stimulating hormone (MSH). Following chronic electrode placement, a base-line and sham-injected EEG pattern was obtained.
Sandman, Curt A
core   +1 more source

Peptide hormones - Adrenocorticotropic Hormone (ACTH)

Peptide hormones, for instance Adrenocorticotropic Hormone (ACTH, pituitary hormone), Alpha-Melanocyte-Stimulating Hormone (α-MSH, Melanocortin), Luteinizing Hormone (LH), Cholecytokinin, and Follicle Stimulating Hormone (FSH), measured with traditional ...
TRacking Adolescents' Individual Lives Survey
core   +1 more source

Quantification of appetite-regulating hormones in children with hypothalamic and common obesity. [PDF]

J Endocr Soc
Gan HW, Leeson C, Aitkenhead H, Spoudeas HA, Dattani MT.   +4 more
europepmc   +1 more source