Results 141 to 150 of about 76,131 (358)

PHARMACEUTICAL FORMS USED IN DEPIGMENTATION

Romanian Journal of Oral Rehabilitation, 2023
The aim of this work is to propose therapeutic formulas for the treatment of pigmentation disorders, in the context of the high incidence of this dermatological pathology The work gives a broad presentation of pigmentation disorders, starting from the
Olimpia Dumitriu Buzia, Kamel Earar, Mihaela Cojocaru, Denisa Batir Marin, Carmen Tiutiucă, Sergiu Ciprian Focșăneanu, Oleg Solomon, Emil Ceban   +7 more
doaj  

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4 [PDF]

, 2017
Background: The transcription factor interferon regulatory factor 4 (IRF4) was identified to be involved in human pigmentation by genome-wide association studies (GWASs).
Cai, Xinzhang, Chen, Hongsheng, Feng, Yong, He, Chufeng, Li, Jiada, Liu, Huadie, Liu, Xueming, Liu, Yalan, Mei, Lingyun, Peng, Zhen, Song, Jian, Vleminckx, Kris   +11 more
core   +1 more source

Immunological and Viral Profiles of Squamous Cell Carcinoma in Transplant and Non‐Transplant Patients in Singapore

JEADV Clinical Practice, EarlyView.
Cutaneous squamous cell carcinoma (cSCC) exhibits a pro‐tumorigenic immune environment, increased oncologic signalling, and tumour remodelling, with three immune subgroups from ‘cold’ to ‘hot’. Organ transplant recipients (OTR) with cSCC showed reduced T‐cells and greater viral enrichment, especially HPV, and a higher disease burden.
Choon Chiat Oh, Boon Yee Lim, Elizabeth Chun Yong Lee, Bavani Kannan, Po Yin Tang, Tun Kiat Ko, Clara Wei Teng Koh, Kuan Rong Chan, Jason Yongsheng Chan   +8 more
wiley   +1 more source

A Diagnosis of Dysplastic Naevus has no Clinical Relevance and Unnecessarily Confounds Therapeutic Decision‐Making

JEADV Clinical Practice, EarlyView.
ABSTRACT The term ‘dysplastic naevus’ first introduced in 1980, has since engendered considerable debate regarding its ontological legitimacy, the appropriateness of its nomenclature, and its potential prognostic significance. In this review, we undertake a critical examination of the extant literature, including a focus on the past decade.
Cliff Rosendahl, Simon Clark, Syril Keena T. Que, Denis Moir, Harald Kittler, Jane M. Grant‐Kels   +5 more
wiley   +1 more source

Low-Dose Melittin Enhanced Pigment Production Through the Upregulation of Tyrosinase Activity and Dendricity in Melanocytes by Limiting Oxidative Stress: A Therapeutic Implication for Vitiligo

Antioxidants
Melittin is a major active ingredient of the bee venom produced by honeybees (Apis mellifera) that exerts various biological effects, such as anti-inflammatory, anti-tumor, anti-microbial, and antioxidant.
Manoj Kumar Tembhre, Shipra
doaj   +1 more source

Tumor‐infiltrating lymphocyte therapy and the mucosal melanoma treatment landscape

Cancer Communications, EarlyView.
Jennifer Thomas, Max Julve, James Larkin, Andrew Furness   +3 more
wiley   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

Uncovering the Role of DNA Repair Impairment in UVA‐Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Ultraviolet A (UVA) radiation induces DNA damage both directly, by forming cyclobutane pyrimidine dimers (CPDs), and indirectly, by generating oxidative stress. Cells rely on nucleotide excision repair (NER) and translesion synthesis (TLS) to tolerate these lesions.
Camila Corradi, Natália Cestari Moreno, Nathalia Quintero‐Ruiz, Giovana da Silva Leandro, Marcela Teatin Latancia, Tiago Antonio de Souza, Veridiana Munford, Carlos Frederico Martins Menck   +7 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source