Results 311 to 320 of about 123,035 (391)

Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation. [PDF]

Int J Mol Sci
Hong S, Lim H, Kim DH.
europepmc   +1 more source

Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials—A Narrative Review

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Hypertrophic scars and keloids, types of pathological scars, arise from dysregulated wound healing, marked by abnormal fibroblast activation and excessive extracellular matrix (ECM) deposition. Current treatments have high recurrence rates and side effects, necessitating targeted therapies. Exosomes, extracellular vesicles mediating
Mengke Wu, Jianfeng Zhang, Na Xiong, Yixiao Ma, Lingling Yong, Huaxu Liu, Qin Guo   +6 more
wiley   +1 more source

Role of Autophagy Induced by Pmel17 in the Pathogenesis of Vitiligo. [PDF]

J Inflamm Res
Sun L, Sun J, Feng Y, Zhu L, Li H, Xu C, Guo C.   +6 more
europepmc   +1 more source

Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou, Sha Sha, Xiangnan Zhou, Chundi He, Ting Xiao, Yan Wu, Fenqin Chen, Le Qu, Hong‐Duo Chen   +8 more
wiley   +1 more source

Transcriptomic insights into the effects of tyrosine on sub-Columbian plumage in H line chickens. [PDF]

Front Vet Sci
Wang X, Zhang L, Yang L, Yang P, Qiao Y, Han Z, Fan J, Li Q, Zhang D, Li Z, Kang X, Du J, Li R.   +12 more
europepmc   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, Volume 600, Issue 1, Page 20-38, January 2026.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Developmental Expression of Membrane Pumps and Ion Channels in Human Vestibular Endolymph Homeostasis. [PDF]

Dev Neurobiol
van Beelen ESA, van der Valk WH, de Groot JCMJ, van Benthem PPG, Locher H.   +4 more
europepmc   +1 more source

Dacarbazine as a Positive Control in Melanoma Cell Lines (A375, SK‐MEL‐103, 1205Lu) and a Human Ex Vivo Skin Model

Advanced Biology, Volume 10, Issue 1, January 2026.
The work seeked to demonstrate the drug Dacarbazine as a positive control for toxicity tests in immortalized skin cells (keratinocytes and fibroblasts) and in different neoplastic cell lines, through the assay with resazurin. In addition, an alternative model to replace animals in experimental studies, using skin explant culture (hOSEC ‐ human ...
Marcel Nani Leite, Natália Aparecida de Paula Rios, Juliana Santos Rosa Viegas, Maria Vitória Lopes Badra Bentley, Leandra Náira Zambelli Ramalho, Enilza Maria Espreafico, Marco Andrey Cipriani Frade   +6 more
wiley   +1 more source

Disrupting melanin transfer: innovative strategy for anti-pigmentation drug discovery. [PDF]

J Enzyme Inhib Med Chem
Niu X, Zhi J, Feng M, Wang S, Feng X, Jiang X, Chen W, Bai R.   +7 more
europepmc   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source