Results 211 to 220 of about 552,068 (289)

Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression. [PDF]

Mol Cancer
Rasbach E, Migayron L, Brandenburg A, Singh P, Martins C, Kassem A, Karkempetzaki AI, Suessner N, Kulcsar Z, Riopedre J, Silva M, Zhen E, Xu S, Mucciarone K, Holzgruber J, Williams JB, Birgin E, Levesque MP, Martínez-Gómez JM, Dummer R, Landsberg J, Lian CG, Murphy GF, Berdan EL, Sui SH, Kupper TS, Rahbari NN, Lee N, Barthel SR, Schatton T.   +29 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Exploring the Link Between PACAP Signalling and Hyaluronic Acid Production in Melanoma Progression. [PDF]

Int J Mol Sci
Hajdú T, Kovács P, Katona É, Nguyen MN, Vágó J, Fillér C, Zákány R, Emri G, Tóth G, Reglődi D, Juhász T.   +10 more
europepmc   +1 more source

Expression, functions, and new target genes of the transcription factor SOX10 in human melanoma

, 2016
Saskia A. Graf
openalex   +2 more sources

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Charting the growth of programmed cell death studies in uveal melanoma: a bibliometric evidence. [PDF]

Discov Oncol
Zhang J, Li L.
europepmc   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Secondary Glaucoma Resulting From Choroidal Melanoma in a Patient With Congenital Nevus of Ota. [PDF]

Case Rep Ophthalmol Med
Petchyim S, Pongrujikorn S, Lizarondo FPJ, Manuskiatti W.   +3 more
europepmc   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Retro- and prospective histologic and immunohistochemical analysis of safety margins following complete excision of less than 1 mm melanomas. [PDF]

Melanoma Res
Bouillenne A, Quatresooz P, Collins P, Nikkels AF.   +3 more
europepmc   +1 more source