Results 211 to 220 of about 933,936 (328)

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Subungual melanoma of the fifth digit: A case report of a rare cutaneous malignancy documented in Syria. [PDF]

Medicine (Baltimore)
Haj Osman O, Alsayed Y, Abo Saada S, Alkhamis A, Hintaieh N, Ghabreau L, Etr A.   +6 more
europepmc   +1 more source

Figure S5 from PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

Neel Jasani, Xiaonan Xu, Benjamin Posorske, Yumi Kim, Kaizhen Wang, Olga Vera, Kenneth Y. Tsai, Gina M. DeNicola, Florian A. Karreth   +8 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

The Diagnostic and Prognostic Role of Combined <i>p16</i> and <i>MTAP</i> Immunohistochemistry in Melanocytic Tumors of Uncertain Malignant Potential: A Comprehensive Review and Clinical Practice Analysis. [PDF]

Int J Mol Sci
Pepe L, Fiorentino V, Pizzimenti C, Martini M, Santarpia M, Fazio A, Vaccaro M, Lentini M, Ieni A.   +8 more
europepmc   +1 more source

Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

, 2008
M. Isabel Burguete, Francisco Galindo, Raquel Gavara, Santiago V. Luis, Miguel Moreno, Paul Thomas, David A. Russell   +6 more
openalex   +2 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Sentinel Node Biopsy for Head and Neck Melanoma: A 12-Year Experience from a Medium-Volume Regional Center. [PDF]

J Clin Med
Lázár P, Boa K, Mezőlaki N, Varga Z, Besenyi Z, Varga E, Németh IB, Baltás E, Oláh J, Kis EG, Piffkó J, Paczona R.   +11 more
europepmc   +1 more source

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

, 1990
Koko Sugawara, Masami Hatori, Yuji Nishiyama, Koji Tomita, Hideo Kamei, MASATAKA KONISHI, TOSHIKAZU OKI   +6 more
openalex   +2 more sources

Pigmentation & Melanoma [PDF]

Journal of Investigative Dermatology, 2015
openaire   +2 more sources