Results 211 to 220 of about 869,771 (326)

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang   +14 more
wiley   +1 more source

Studies of the Antigenicity of Human Malignant Melanoma for Rabbits

open access: bronze, 1966
Inga Silberberg   +2 more
openalex   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin   +9 more
wiley   +1 more source

The impact of the COVID-19 pandemic on melanoma diagnosis: a systematic review and meta-analysis of global evidence. [PDF]

open access: yesBMC Public Health
Mostafavi Zadeh SM   +5 more
europepmc   +1 more source

Effect of coley's toxins and irradiation on the A. Melanoma #3 tumor in the golden hamster [PDF]

open access: bronze, 1968
Sarah S. Donaldson   +2 more
openalex   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

open access: yesAdvanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li   +9 more
wiley   +1 more source

Prognostic significance of sentinel node tumor burden in Merkel Cell Carcinoma

open access: yesEJC Skin Cancer
L. Zijlker   +14 more
doaj   +1 more source

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