Results 221 to 230 of about 869,771 (326)

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

open access: yesAdvanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong   +18 more
wiley   +1 more source

Multimodal imaging of tumour-related lipid exudation and exudative retinal detachment following brachytherapy in choroidal melanoma. [PDF]

open access: yesBMC Ophthalmol
Ros-Sanchez E   +6 more
europepmc   +1 more source

Histogenesis of malignant melanomas of the uvea.II. Relationship of uveal nevi to malignant melanomas [PDF]

open access: bronze, 1967
Myron Yanoff, Lorenz E. Zimmerman
openalex   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

open access: yesAdvanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro   +10 more
wiley   +1 more source

Malignant melanomas of the skin

open access: bronze, 1962
Nora Petersen   +2 more
openalex   +1 more source

Metastatic malignant melanoma from mother to fetus [PDF]

open access: bronze, 1965
Isadore Brodsky   +4 more
openalex   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan   +8 more
wiley   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

open access: yesAdvanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai   +5 more
wiley   +1 more source

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