Results 111 to 120 of about 7,378 (211)

Local Retinal Circuits of Melanopsin-Containing Ganglion Cells Identified by Transsynaptic Viral Tracing [PDF]

Current Biology, 2007
Intrinsically photosensitive melanopsin-containing retinal ganglion cells (ipRGCs) control important physiological processes, including the circadian rhythm, the pupillary reflex, and the suppression of locomotor behavior (reviewed in [1]). ipRGCs are also activated by classical photoreceptors, the rods and cones, through local retinal circuits [2, 3].
Viney, Tim James, Balint, Kamill, Hillier, Daniel, Siegert, Sandra, Boldogkoi, Zsolt, Enquist, Lynn W., Meister, Markus, Cepko, Constance L., Roska, Botond   +8 more
openaire   +3 more sources

Circadian rhythm dysfunction in glaucoma: A hypothesis

Journal of Circadian Rhythms, 2008
The absence of circadian zeitgebers in the social environment causes circadian misalignment, which is often associated with sleep disturbances. Circadian misalignment, defined as a mismatch between the sleep-wake cycle and the timing of the circadian ...
Jean-Louis Girardin, Zizi Ferdinand, Lazzaro Douglas R, Wolintz Arthur H   +3 more
doaj   +1 more source

Hypothalamic Orexin Projections to the Hippocampal CA1 Region Alleviate Cognitive and Synaptic Plasticity Impairments Induced by Blue Light Exposure

CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
The neural pathways from hypothalamic orexin neurons to the hippocampus improve the impairment of learning and memory induced by blue light exposure, revealing the mechanism of improved damage caused by blue light. ABSTRACT Background and Objectives Exposure to blue light emitted from electronic devices has been shown to impair cognitive performance ...
Zhe Feng, Qingqing Li, Zhenquan He, Baocong Yu, Ting Mi, Jiandong Niu, Yuhong He, Qi Li, Xi Chen, Jianguo Niu, Dan Ding   +10 more
wiley   +1 more source

Mouse ganglion-cell photoreceptors are driven by the most sensitive rod pathway and by both types of cones.

PLoS ONE, 2013
Intrinsically photosensitive retinal ganglion cells (iprgcs) are depolarized by light by two mechanisms: directly, through activation of their photopigment melanopsin; and indirectly through synaptic circuits driven by rods and cones. To learn more about
Shijun Weng, Maureen E Estevez, David M Berson   +2 more
doaj   +1 more source

Alerting or Somnogenic Light: Pick Your Color. [PDF]

, 2016
In mammals, light exerts pervasive effects on physiology and behavior in two ways: indirectly through clock synchronization and the phase adjustment of circadian rhythms, and directly through the promotion of alertness and sleep, respectively, in diurnal
Bourgin, P., Hubbard, J.
core   +3 more sources

Adaptations of the Vertebrate Retina to Low‐Light Conditions: A Review

Anatomia, Histologia, Embryologia, Volume 54, Issue 4, July 2025.
ABSTRACT Vision is a critical sensory modality in vertebrates, enabling diverse adaptations to environmental challenges. This review explores the remarkable adaptations of vertebrate eyes to low‐light environments, such as nocturnal habitats, deep‐sea ecosystems and subterranean niches.
R. Cobo, A. Navarro‐Sempere, Y. Segovia, M. García   +3 more
wiley   +1 more source

Melanopsin retinal ganglion cell loss and circadian dysfunction in Alzheimer's disease (Review)

Molecular Medicine Reports, 2016
Alzheimer's disease affects 27 million individuals and is the most common cause of dementia worldwide. The pathology of Alzheimer's disease is primarily due to the β‑amyloid deposits and neurofibrillary tangles. These deposits exist largely in the cerebral blood vessels, but have also been shown to exist in retinal vessels.
FENG, RUIQI, LI, LIJUAN, YU, HAIYAN, LIU, MIN, ZHAO, WEI   +4 more
openaire   +3 more sources

Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses.

PLoS ONE, 2008
Rod/cone photoreceptors of the outer retina and the melanopsin-expressing retinal ganglion cells (mRGCs) of the inner retina mediate non-image forming visual responses including entrainment of the circadian clock to the ambient light, the pupillary light
Megumi Hatori, Hiep Le, Christopher Vollmers, Sheena Racheal Keding, Nobushige Tanaka, Thorsten Buch, Ari Waisman, Christian Schmedt, Timothy Jegla, Satchidananda Panda   +9 more
doaj   +1 more source

Central melanopsin projections in the diurnal rodent, Arvicanthis niloticus [PDF]

, 2015
The direct effects of photic stimuli on behavior are very different in diurnal and nocturnal species, as light stimulates an increase in activity in the former and a decrease in the latter. Studies of nocturnal mice have implicated a select population of
Esquiva, Gema, Hannibal, Jens, Langel, Jennifer L., Smale, Laura   +3 more
core   +2 more sources

Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Light influences human physiology profoundly, affecting the circadian clock and suppressing the endogenous hormone melatonin. Experimental studies often employ either homogenous full‐field stimulation, or overhead illumination, which are hard to standardize across studies and laboratories.
Maydel Fernandez‐Alonso, Manuel Spitschan   +1 more
wiley   +1 more source