Results 1 to 10 of about 37,493 (266)

Impaired respiratory function in MELAS‐induced pluripotent stem cells with high heteroplasmy levels

FEBS Open Bio, 2015
Mitochondrial diseases are heterogeneous disorders, caused by mitochondrial dysfunction. Mitochondria are not regulated solely by nuclear genomic DNA but by mitochondrial DNA.
Masaki Kodaira, Shinsuke Yuasa, Tomohisa Seki   +2 more
exaly   +2 more sources

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis: A case report

Radiology Case Reports, 2022
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presents with the features of herpes simplex encephalitis (HSE), which is rare and has been described in only a few case reports.
Wen-Gao Zeng, MD, Wan-Min Liao, PhD, Jue Hu, PhD, Su-Fen Chen, MD, Zhen Wang, PhD   +4 more
doaj   +2 more sources

Dynamic reconfiguration and transition of whole-brain networks in patients with MELAS revealed by a hidden Markov model [PDF]

Frontiers in Neurology
ObjectivesMitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a rare maternally inherited disease. The neuropathologic mechanisms and neural network alterations underlying stroke-like episodes (SLEs), a recurrent ...
Qingyun Yu, Qingyun Yu, Rong Wang, Chong Sun, Bin Hu, Xueling Liu, Liqin Yang, Jie Lin, Daoying Geng, Daoying Geng, Daoying Geng, Yuxin Li   +11 more
doaj   +2 more sources

Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS): diagnostic criteria, features of epileptic seizures, and treatment approaches by the example of a clinical case

Неврология, нейропсихиатрия, психосоматика, 2017
The paper describes a patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS). The features of  the course and therapy of epilepsy in MELAS are discussed.
M. A. Yamin, I. V. Chernikova, L. V. Araslanova, P. A. Shevkun   +3 more
doaj   +3 more sources

MELAS syndrome complicated by anti-GFAP autoantibody positivity: a case report and literature review [PDF]

BMC Neurology
Background Autoimmune abnormalities have been reported in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, but anti-glial fibrillary acidic protein (GFAP) antibody positivity in both serum and cerebrospinal ...
Jun Shu, Yiping Zhou, Ziwei Xu, Wenshi Wei, Lirong Zhao, Jie Chang   +5 more
doaj   +2 more sources

Migratory vasodilatation of cerebral arteries in MELAS episodes: a case report and literature review [PDF]

Frontiers in Immunology
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is the commonest inherited mitochondrial disorder. Dilation of the major cerebral arteries is seldom mentioned in MELAS because magnetic resonance angiography (MRA ...
Ying Luo, Quanhong Chu, Quanhong Chu, Taochun Yu, Xiaoqing Lu, Xiaoqing Lu, Yanmei Wang, Yanmei Wang, Jie Li, Jie Li, Lingfeng Wu, Lingfeng Wu, Yaoyao Shen, Yaoyao Shen   +13 more
doaj   +2 more sources

Case Report: Simultaneous pancreas–kidney transplantation in MELAS: first reported case with 5-year follow-up [PDF]

Frontiers in Transplantation
BackgroundMitochondrial encephalomyopathy with lactic acidosis, and stroke-like episodes (MELAS) is a rare mitochondrial DNA disorder that, in severe cases, can result in insulin-dependent diabetes and end-stage renal disease (ESRD).
Vera Nilsén, Vera Nilsén, Julia Bojstedt, Johan Nordström, Johan Nordström   +4 more
doaj   +2 more sources

Retinal multimodal-imaging and functional tests in a mitochondrial disease with focal and segmental glomerulosclerosis [PDF]

International Journal of Ophthalmology
The phenotypes of the adenine-to-guanine transition at position 3243 of mitochondrial DNA (m.3243A>G) are highly variable, with different symptoms observed in different patients.
Xiao-Hong Liu, Xi Shen, Yi-Sheng Zhong
doaj   +2 more sources

Vitelliform maculopathy in MELAS syndrome

American Journal of Ophthalmology Case Reports, 2023
Purpose: We present a unique case of foveomacular vitelliform lesions in a patient with metabolic encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS).
Cody Jahrig, Cristy A. Ku, Molly Marra, Mark E. Pennesi, Paul Yang   +4 more
doaj   +2 more sources

The clinical spectrum of MELAS and associated disorders across ages: a retrospective cohort study

Frontiers in Neurology, 2023
ObjectiveMitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a severe multisystemic disease, although some have a milder phenotype.
Benjamin C. Cox, Jennifer Y. Pearson, Jay Mandrekar, Ralitza H. Gavrilova   +3 more
doaj   +1 more source