Results 11 to 20 of about 15,344 (194)

Melioidosis in Asia‐Pacific Nations: Expanding Boundaries but Unknowns Remain [PDF]

Respirology, Volume 30, Issue 10, Page 917-919, October 2025.
Bart J. Currie, Ella M. Meumann
openalex   +2 more sources

Comparison of TaqMan PCR assays for detection of the melioidosis agent Burkholderia pseudomallei in clinical specimens [PDF]

, 2012
Melioidosis is an emerging infectious disease caused by the soil bacterium Burkholderia pseudomallei. In diagnostic and forensic settings, molecular detection assays need not only high sensitivity with low limits of detection but also high specificity ...
Bowers, Jolene R., Colman, Rebecca E., Currie, Bart J., Engelthaler, David M., Kaestli, Mirjam, Keim, Paul S., Kelley, Erin, Mayo, Mark, Pearson, Talima, Price, Erin P., Richardson, Leisha J., Sarovich, Derek S., Schupp, James M., Seymour, Meagan L., Tuanyok, Apichai, Wagner, David M.   +15 more
core   +4 more sources

Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen burkholderia pseudomallei K96243 [PDF]

, 2010
Burkholderia pseudomallei is an important human pathogen whose infection biology is still poorly understood. The bacterium is endemic to tropical regions, including South East Asia and Northern Australia, where it causes melioidosis, a serious disease ...
Bentley, Stephen D., Dowling, Andrea J., ffrench-Constant, Richard H., Holden, Matthew T. G., Quail, Michael A., Reger, Julia, Titball, Richard W., Waterfield, Nicholas R., Wilkinson, Paul A.   +8 more
core   +7 more sources

Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis [PDF]

, 2009
BACKGROUND: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and Infectious Diseases (NIAID) as a category B priority agent.
Banchereau, Jacques, Bancroft, Gregory J, Berry, Matthew, Blankenship, Derek M, Buddhisa, Surachat, Chaussabel, Damien, Lertmemongkolchai, Ganjana, Pankla, Rungnapa   +7 more
core   +3 more sources

Neurologic Melioidosis [PDF]

The American Society of Tropical Medicine and Hygiene, 2013
Melioidosis is an important cause of morbidity and mortality in northern Australia and Southeast Asia. Diagnosis is best made by isolation of Burkholderia pseudomallei from clinical specimens. A variety of clinical presentations are described, including neurologic disease.
Martin, Deuble, Chloe, Aquilina, Robert, Norton   +2 more
openaire   +2 more sources

Less is more: Burkholderia pseudomallei and chronic melioidosis [PDF]

, 2013
10.1128/mBio.00709 ...
Chantratita, Cruz-Migoni, Currie, Currie, Darling, Everett, Falade, Hayden, Hodgson, Holden, Losada, Nandi, Price, Price, Smith, West, White, Wiersinga   +17 more
core   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +2 more sources

Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei. [PDF]

, 2017
Melioidosis, caused by Burkholderia pseudomallei, is endemic in northeastern Thailand and Northern Australia. Severe septicemic melioidosis is associated with high levels of pro-inflammatory cytokines and is correlated with poor clinical outcomes.
A Easton, A Haque, A Novikov, A O’Garra, AC Cheng, AJ Simpson, BJ Currie, C Kewcharoenwong, CA Rowland, CR Romero, D Limmathurotsakul, D Limmathurotsakul, D Limmathurotsakul, D Suwannasaen, FN Lauw, G Lertmemongkolchai, GC Koo, GC Ulett, GC Ulett, GCKW Koh, GCKW Koh, J Chen, J Morris, J-X See, JM Pitt, JR Teijaro, JU Igietseme, K Breitbach, KA Hodgson, KN Couper, KS Tan, KW Moore, L Conejero, M Kortylewski, M Saraiva, MJ Greenberger, MM Kane, MP Moutschen, MTG Holden, N Chantratita, N White, P Saengmuang, P Santanirand, P Tippayawat, P Trzonkowski, PS Redford, R Sabat, S Chanchamroen, SA Dalrymple, TAF Weehuizen, V Wuthiekanun, W Aekplakorn, WJ Wiersinga, Y Homma, Y Suputtamongkol   +54 more
core   +1 more source

Bioluminescent Diagnostic Imaging to Characterize Altered Respiratory Tract Colonization by the Burkholderia Pseudomallei Capsule Mutant [PDF]

, 2011
Pneumonia is a common manifestation of the highly fatal disease melioidosis, caused by the select agent bacteria Burkholderia pseudomallei. In this study we describe a new model system to investigate pulmonary melioidosis using bioluminescent-engineered ...
Jonathan Mark Warawa, Jonathan Mark Warawa, Dan eLong, Rebecca eRosenke, Don eGardner, Frank eGherardini   +5 more
core   +1 more source

Human Melioidosis

Clinical Microbiology Reviews, 2020
The causative agent of melioidosis,Burkholderia pseudomallei, a tier 1 select agent, is endemic in Southeast Asia and northern Australia, with increased incidence associated with high levels of rainfall. Increasing reports of this condition have occurred worldwide, with estimates of up to 165,000 cases and 89,000 deaths per year.
I. Gassiep, M. Armstrong, R. Norton
openaire   +4 more sources