Results 221 to 230 of about 18,137 (273)

A Clinical Study for the Development of a Bee Venom Allergy Diagnostic Kit. [PDF]

open access: yesJ Pharmacopuncture
Yu JS   +5 more
europepmc   +1 more source

Melittin inhibits proliferation, migration, and invasion in osteosarcoma cell lines using 2D and 3D models. [PDF]

open access: yesJ Venom Anim Toxins Incl Trop Dis
Pedro G   +4 more
europepmc   +1 more source
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Melittin-phospholipid interaction Evidence for melittin aggregation

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1981
Abstract The fluorescence spectra of the single tryptophan residue of melittin in 0.15 M potassium phosphate solution and when bound to egg phosphatidylcholine bilayer liposomes practically coincide and exhibit a large blue shift relative to that in aqueous solution.
S, Georghiou   +2 more
openaire   +2 more sources

Melittin-regenerated purple membrane

Biochemistry (Moscow), 2009
We have investigated the character of melittin-regenerated purple membrane. Adding melittin to blue membrane causes the color transition and partial regeneration of the photocycle and the proton pump. The reconstitution of bacteriorhodopsin by melittin is proved to be charge-dependent.
Yue, Zhang, Tao, Su, Kun-Sheng, Hu
openaire   +2 more sources

Melittin and Cancer

Journal of Apitherapy, 2016
Cancer no longer is the automatic death sentence of centuries past, yet it remains a leading cause of global morbidity and mortality despite advances in detection, treatment, and survival in the field of oncology. The search for natural chemotherapeutic substances has accelerated research into the use of venom as a potential weapon against cancer.
Anna Tacn, PhD PhD
openaire   +1 more source

Molecular parameters in melittin immunogenicity

Journal of Peptide Science, 1997
Based on immunogenicity studies, two T-cell epitopes in melittin were found to be functional in guinea pigs, one being centrally located, the other one residing in the C-terminal chain. In Balb/c mice only the central epitope was found to be active. A human T-cell clone was found by T-cell proliferation studies to employ strictly the C-terminal chain ...
V, Curcio-Vonlanthen   +4 more
openaire   +2 more sources

Picosecond fluorescence spectrochronography of protein melittin and melittin-membrane complexes

Journal of Molecular Structure, 1990
Abstract The results are presented of the study of protein melittin structure and dynamics when incorporated into the phospholipid bilayer carried out by time-resolved fluorescence spectroscopy with laser UV ps-pulse excitation.
A.Yu. Chikishev   +3 more
openaire   +1 more source

Peptide inhibitors of melittin action

Journal of Protein Chemistry, 1996
The sequence of peptides necessary to inhibit melittin-induced lysis was studied using 13 peptide analogues of the inhibitor Ac-IVIFDC-NH2. Although this inhibitor is a disulfide-linked dimer, inhibition was equally effective if the thiol SH was blocked or replaced by methionine or lysine.
D, Hewish   +5 more
openaire   +2 more sources

Membrane matrix disruption by melittin

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1972
Abstract Electron spin resonance spectroscopy was used to examine the interaction of the lytic polypeptide, melittin, with model membrane systems in order to determine the physical basis for its alterations of membrane properties. Sonically dispersed egg lecithin (phosphatidylcholine), phosphatidylserine, extracted Escherichia coli phospholipids, and
J C, Williams, R M, Bell
openaire   +2 more sources

Melittin lysis of red cells

The Journal of Membrane Biology, 1985
This paper describes experiments designed to explore interactions between human red blood cell membranes and melittin, the main component of bee venom. We found that melittin binds to human red cell membranes suspended in isotonic NaCl at room temperature, with an apparent dissociation constant of 3 X 10(-8) M and maximum binding capacity of 1.8 X 10(7)
M T, Tosteson   +3 more
openaire   +2 more sources

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