Results 91 to 100 of about 17,671 (204)

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

The Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu, Andrew E. Worthy, Alan J. Emanuel   +2 more
wiley   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Patient Experiences of Chronic Low Back Pain: Development of a Conceptual Model Based on a Targeted Literature Review and Qualitative Patient Interviews

Musculoskeletal Care, Volume 24, Issue 4, December 2026.
ABSTRACT Purpose Chronic low back pain (CLBP) is a persistent, debilitating condition. The United States (US) Food and Drug Administration Patient‐Focused Drug Development Guidance recommends using patient‐reported outcome (PRO) measures to assess pain and function in clinical trials and document content validity of the measures based on patient ...
Ekin Seçinti, Brittany Klooster, Rebecca Robinson, Madison C. Bernstein, Madeline Tallarico, Kaitlin Chatterton, Adriana Voci, Daniella Olonilua, Samantha R. Linton, Leighann Litcher‐Kelly, Marcia M. Mellado Lagarde, Linda A. Wietecha, John Markman   +12 more
wiley   +1 more source

Progenitor Timing Shapes NG2‐Glia Fate and Oligodendrocyte Differentiation

Glia, Volume 74, Issue 11, November 2026.
Developmental timing defines NG2‐glia and oligodendrocyte fate. E16 NG2‐progenitors produce large, more dispersed NG2‐glia clones. P0 progenitors show a bias toward oligodendrocyte differentiation. Temporal windows establish long‐term cortical glial heterogeneity.
Ana Cristina Ojalvo‐Sanz, Carolina Pernia‐Solanilla, Laura López‐Mascaraque   +2 more
wiley   +1 more source

A Model for Estimating the Risk of Gastrointestinal Bleeding for Patients on Oral Anticoagulants and Interacting Medications

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 11, November 2026.
ABSTRACT Introduction Pharmacodynamic drug–drug interactions (DDI) in patients receiving oral anticoagulants (OAC) may increase the risk of gastrointestinal bleeding (GIB). The purpose of this study was to develop and validate a GIB model for patients receiving OACs.
Ainhoa Gomez‐Lumbreras, Abdelrahman G. Tawfik, Thomas Reese, Daniel M. Witt, Guilherme Del Fiol, Daniel C. Malone   +5 more
wiley   +1 more source

Influence of Rosuvastatin and Meloxicam on Radiation-Induced Genetic Damage in Healthy Lymphocytes and Leukemia HL-60 Cells [PDF]

مجله دانشگاه علوم پزشکی گیلان
Background: Radiotherapy plays a crucial role in cancer treatment; however, a significant challenge is the resistance of cancer cells to radiation, as well as the adverse effects that ionizing radiation can have on adjacent healthy cells. Objective: This
Mona Haddad Zahmatkesh, hamid saeidi saedi, Setareh hosseinpour, zeinab taghavi   +3 more
doaj  

Femoral‐sciatic nerve block by levobupivacaine for a case of cheetah (Acinonyx jubatus) with metatarsal fracture

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract Femoral‐sciatic nerve block is commonly used regional anaesthetic technique in small animal clinical practice. However, no previous reports are available about femoral‐sciatic nerve block in cheetahs. This case report describes a femoral‐sciatic nerve block using levobupivacaine in a cheetah that had undergone a metatarsal fracture treatment ...
Harumichi Itoh, Kazuhito Itamoto, Azusa Sato   +2 more
wiley   +1 more source

Intrahousehold aggression in two dogs with pain experience as the primary motivational factor of the dogs’ aggressive behaviours

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract We present two cases of intrahousehold aggression in dogs experiencing undiagnosed physical discomfort, including pain. Pain was expected to be a motivational factor, as a physical issue marked the start of the aggression and as not all stimuli were related to the dogs’ direct external environment, pointing at possible internal stimuli. Victim‐
I. R. van Herwijnen, S. M. A. Gardeweg, C. M. Vinke, P. Schulte, D. Hartman   +4 more
wiley   +1 more source

Surgical resolution of intestinal prolapse due to intussusception in a Djungarian hamster (Phodopus sungorus)

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Summary A 13‐month‐old, male Djungarian hamster (Phodopus sungorus) presented to our veterinary clinic with a 2‐day history of mild decreased appetite and reduced activity, and a prolapse from the anus. On physical examination, a 15‐mm intestinal prolapse was identified. Ultrasound suggested intussusception and revealed no additional lesions or foreign
Urarako Shimizu, Kazutaka Yamada
wiley   +1 more source