Results 31 to 40 of about 35,513 (277)

Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2- dependent and -independent pathways.

PLoS ONE, 2014
BackgroundCyclooxygenase (COX)-2 is overexpressed in many types of cancers including hepatocellular carcinoma (HCC). Meloxicam, a selective COX-2 inhibitor, has shown potential therapeutic effects against HCC, but the mechanisms accounting for its anti ...
Xiaofeng Dong, Rui Li, Peng Xiu, Xuesong Dong, Zongzhen Xu, Bo Zhai, Feng Liu, Hongchi Jiang, Xueying Sun, Jie Li, Haiquan Qiao   +10 more
doaj   +1 more source

Design of Etched- and Functionalized-Halloysite/Meloxicam Hybrids: A Tool for Enhancing Drug Solubility and Dissolution Rate

Pharmaceutics
The study focuses on the synthesis and characterization of Meloxicam–halloysite nanotube (HNT) composites as a viable approach to enhance the solubility and dissolution rate of meloxicam, a poorly water-soluble drug (BCS class II). Meloxicam is loaded on
Valeria Friuli, Claudia Urru, Chiara Ferrara, Debora Maria Conti, Giovanna Bruni, Lauretta Maggi, Doretta Capsoni   +6 more
doaj   +1 more source

MELOXICAM-INDUCED GASTROPATHY IN DOGS: CLINICAL, BIOCHEMICAL, ENDOSCOPIC FEATURES AND TRIALS FOR PREVENTION

Slovenian Veterinary Research, 2023
This study was conducted to evaluate and to compare the clinical, hemato-biochemical and endoscopic aspects of gastropathy in dogs treated with meloxicam alone or incombination with esomeprazole and misoprostol.
Gehad Ezzat Nassar, Yasmin Hassan Bayumi, Hatem Mohammed Selim, Shimaa Ezzeldein   +3 more
doaj   +1 more source

Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats [PDF]

, 2016
The objective of this study was to model the pharmacokinetics (PKs) of robenacoxib in cats using a nonlinear mixed‐effects (NLME) approach, leveraging all available information collected from cats receiving robenacoxib s.c.
Beal, Benet, Dziak, Fink, Giraudel, Jung, King, Lainesse, Lascelles, Lavielle, Lavielle, Lees, Lehr, Martin-Jiménez, Mochel, Mochel, Pelligand, Pelligand, Savic, Sheiner, Sheiner, Sheiner, Silber, Thomasy, Toutain, Toutain, Toutain, Xu   +27 more
core   +2 more sources

Adaptive responses of Gordonia alkanivorans IEGM 1277 to the action of meloxicam and its efficient biodegradation

Frontiers in Bioengineering and Biotechnology
IntroductionPharmaceutical contaminants such as meloxicam pose significant environmental risks due to their persistence and toxicity. The biodegradation potential of actinomycetes, particularly representatives of Gordonia, offers promising avenues for ...
Semyon Tyan, Nadezhda Kostrikina, Vladimir Sorokin, Andrey Mulyukin, Irina Ivshina   +4 more
doaj   +1 more source

Effect of Meloxicam and Nano-meloxicam on selected haematological and immunological parameters in arthritis-induced male albino rats

Babcock University Medical Journal
Objective: This study aimed to evaluate the effects of meloxicam and nano-meloxicam on haematological parameters and cytokine levels in an animal model of arthritis.
Adel Bashar, Wejdan Kadhem
doaj   +1 more source

In Vitro Studies on the Influence of Meloxicam on Cytotoxic Activity Induced by Risedronate Sodium in Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

Animals, 2021
The study describes the cytotoxic effect against human and canine osteosarcoma (U-2 OS and D-17) cell lines induced by risedronate sodium and meloxicam per se and in combination.
Dominik Poradowski, Izabela Janus, Aleksander Chrószcz, Bożena Obmińska-Mrukowicz   +3 more
doaj   +1 more source

Intravenous meloxicam for the treatment of moderate to severe acute pain: a pooled analysis of safety and opioid-reducing effects. [PDF]

, 2019
BACKGROUND AND OBJECTIVES: To describe the safety and tolerability of intravenous meloxicam compared with placebo across all phase II/III clinical trials.
Bergese, Sergio, Du, Wei, Gan, Tong J., Hobson, Sue, Mack, Randall J., McCallum, Stewart W., Singla, Neil, Viscusi, Eugene R.   +7 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacokinetic Parameters and Estimating Extra-Label Tissue Withdrawal Intervals Using Three Approaches and Various Matrices for Domestic Laying Chickens Following Meloxicam Administration

Frontiers in Veterinary Science, 2022
Meloxicam is commonly prescribed for treating chickens in backyard or small commercial operations despite a paucity of scientific data establishing tissue withdrawal interval recommendations following extra-label drug use (ELDU).
Emily D. Richards, Emily D. Richards, Rachel S. Dutch, Nathaniel C. Burmas, Jennifer L. Davis, Zhoumeng Lin, Maaike O. Clapham, Maaike O. Clapham, Scott E. Wetzlich, Scott E. Wetzlich, Lisa A. Tell, Lisa A. Tell   +11 more
doaj   +1 more source