Results 91 to 100 of about 25,852 (227)

Pegargiminase Suppresses the Fanconi Anemia Pathway and Promotes Melphalan‐Induced DNA Double‐Strand Breaks in Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
ADI‐PEG20 enhances melphalan‐induced DNA DSBs in UM cells. We describe potentiation of DNA DSBs in UM cell lines upon treatment with ADI‐PEG20 and melphalan (92.1 cells with STRIDE by intoDNA). ADI‐PEG20 suppresses multiple members of the FA pathway—a known resistance mechanism for melphalan—providing a rationale for exploring this drug combination in ...
Iuliia Pavlyk, George Field, Matthew Young, Josephine Carpentier, Emilia A. Szlosarek, Michaela R. O'Keeffe‐Brown, Timothy Crook, Nelofer Syed, John S. Bomalaski, Pui Ying Chan, Peter W. Szlosarek   +10 more
wiley   +1 more source

Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies.

, 2004
BACKGROUND: We have previously shown how tumor response of isolated limb perfusion (ILP) with melphalan was improved when tumor necrosis factor alpha (TNF-alpha) was added.
Bruijn, E.A. (Ernst) de, Hoving, S. (Saske), Guetens, Gunther, Hoving, S., van Tiel, Sandra; id_orcid, Hagen, T.L.M. (Timo) ten, Guetens, G, Brunstein, F. (Flavia), Eggermont, A.M.M. (Alexander), van Tiel, S.T., Seynhaeve, A.L.B. (Ann), Guetens, G. (Gunther), Tiel, S.T. (Sandra) van, Seynhaeve, A.L.B., de Bruijn, Ernst, Brunstein, F (Flavia), Eggermont, A.M.M., ten Hagen, T.L.M., Seynaeve, ALB, Eggermont, Lex, Bruijn, EA, Brunstein, F., ten Hagen, Timo, Hoving, S (Saske)   +23 more
core   +1 more source

Intravitreal Melphalan for Vitreous Seeds: Initial Experience in China [PDF]

, 2016
Purpose. To evaluate the efficacy of intravitreal melphalan for vitreous seeds from retinoblastoma in Chinese patients. Methods. This is a retrospective review of 17 consecutive Chinese patients (19 eyes) with viable vitreous seeds from retinoblastoma ...
Jiakai Li, Xunda Ji, Peiyan Hua, Jing Li, Peiquan Zhao, Junyang Zhao   +5 more
core   +1 more source

Inclusion Complexes of Melphalan with Gemini-Conjugated β-Cyclodextrin: Physicochemical Properties and Chemotherapeutic Efficacy in In-Vitro Tumor Models

Pharmaceutics, 2019
β-cyclodextrin (βCD) has been widely explored as an excipient for pharmaceuticals and nutraceuticals as it forms stable host−guest inclusion complexes and enhances the solubility of poorly soluble active agents.
Waleed Mohammed-Saeid, Abdalla H Karoyo, Ronald E Verrall, Lee D Wilson, Ildiko Badea   +4 more
doaj   +1 more source

Retreatment with talquetamab and pomalidomide in triple‐class–BCMA–GPRC5D refractory myeloma

British Journal of Haematology, EarlyView.
Kian J. Rahbari, Gliceida M. Galarza Fortuna, Bhagirathbhai Dholaria, Douglas W. Sborov, Muhamed Baljevic   +4 more
wiley   +1 more source

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Mechanismus der Leberzellschädigung durch das Zytostatikum Melphalan

, 2004
Isolierte hepatische Perfusion mit Melphalan, Tumor Nekrose Faktor (TNF) und Hyperthermie zur Behandlung von Patienten mit nicht-operablen Lebertumoren ist oft mit akuter Hepatotoxizität assoziiert.
Kresse, Matthias
core  

Gemcitabine, Docetaxel, Melphalan, Carboplatin as Part of Sequential Cycles of High‐Dose Chemotherapy With Autologous Hematopoietic Stem‐Cell Rescue for Multiply Relapsed/Refractory Pediatric Germ Cell Tumors

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost, Olayinka Okeleji, Amr Elgehiny, Douglas Harrison, Cynthia Herzog, Jeremy Connors, Demetrios Petropoulos, Priti Tewari, Dristhi Ragoonanan, Yago Nieto, Irtiza N. Sheikh   +10 more
wiley   +1 more source

Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. [PDF]

, 2008
Bortezomib plus melphalan-prednisone was superior to melphalan-prednisone alone in patients with newly diagnosed myeloma who were ineligible for high-dose therapy. (ClinicalTrials.gov number, NCT00111319.
San-Miguel, Jesus, Dimopoulos, M. A., Schots, Rik, Esseltine, Dixie L, Velde, Helgi van de, Anderson, Kenneth C., van de Velde, Helgi, Spicka, Ivan, Samoilova, Olga S., Dmoszynska, Anna, Esseltine, Dixie-Lee, Petrucci, Maria T., Abdulkadyrov, Kudrat M, Mateos, Maria-Victoria, Kropff, Martin H., Abdulkadyrov, Kudrat M., Dimopoulos, Meletios A., Dimopoulos, Meletios A, Richardson, Paul G, Shpilberg, Ofer, Palumbo, Antonio, San Miguel Izquierdo, Jesús Fernando, Schlag, Rudolf, San Miguel, Jesus F., Richardson, Paul G., Esseltine, Dixie L., Mateos Manteca, María Victoria, Kropff, Martin, Cakana, Andrew, Petrucci, Maria T, Jiang, Bin, Liu, Kevin, Khuageva, Nuriet K, Khuageva, Nuriet K., San Miguel, Jesús F, Anderson, Kenneth C, Samoilova, Olga S   +36 more
core   +1 more source