Results 41 to 50 of about 35,440 (290)

MeltMigrator : a MATLAB-based software for modeling three-dimensional melt migration and crustal thickness variations at mid-ocean ridges following a rules-based approach [PDF]

, 2017
Author Posting. © American Geophysical Union, 2017. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 18 (2017):
Bai, Hailong, Behn, Mark D., Montesi, Laurent G. J.   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Numerical modelling of magma dynamics coupled to tectonic deformation of lithosphere and crust [PDF]

, 2017
Many unresolved questions in geodynamics revolve around the physical behaviour of the two-phase system of a silicate melt percolating through and interacting with a tectonically deforming host rock.
Kaus, Boris J. P., Keller, Tobias, May, Dave A.   +2 more
core  

The break-up of continents and the formation of new ocean basins

, 2002
Rifted continental margins are the product of stretching, thinning and ultimate break-up of a continental plate into smaller fragments, and the rocks lying beneath them store a record of this rifting process.
Minshull, T.A.
core   +1 more source

Geophysical characterisation of the ocean–continent transition at magma-poor rifted margins [PDF]

, 2009
Geophysical characterisation of the ocean-continent transition (OCT) at magma-poor riftedmargins has focused primarily on the determination of P wave velocities using wide-angleseismic techniques. Such experiments have shown that the OCT is heterogeneous,
Minshull, Timothy A.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Repacking Accelerates High‐Silica Melts Extraction: Insights From Microstructural Record and Numerical Modeling

Geophysical Research Letters
Repacking enhances crystal mush permeability, accelerating melt extraction. However, identifying microstructural records of repacking is challenging, creating a gap in quantifying its effect on magmatic reservoirs. We identified extracted melt (rhyolite)
Hou‐Bin Chen, Boda Liu, Wei‐Qiang Ji, Shao‐Hua Zhang, Kai Zhao, Fu‐Yuan Wu   +5 more
doaj   +1 more source

Physics-guided spatiotemporal approach for melt pool size prediction in laser powder bed fusion

Virtual and Physical Prototyping
This study first proposes a physics-guided spatiotemporal graph. The melt pool temporal feature nodes and spatial feature nodes are extracted from melt pool images based on spatiotemporal correlations. These feature points are treated as graph nodes, and
Yangkun Mao, Xin Lin, Haihong Zhu, Kunpeng Zhu   +3 more
doaj   +1 more source

The Meaning of Pressure for Primary Magmas: New Insights From PRIMELT3‐P

Geochemistry, Geophysics, Geosystems, 2023
This paper reports new software, PRIMELT3‐P, for computing the pressure and temperature range over which a primary basaltic magma was formed by adiabatic decompression and fractional melting of fertile mantle peridotite.
Claude T. Herzberg, Paul D. Asimow, Juan David Hernández‐Montenegro   +2 more
doaj   +1 more source