Results 51 to 60 of about 1,257,317 (288)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Geochemical study of the Solchiaro (Procida Island,Campi Flegrei) eruptive products by microthermometry and microanalyses of fluid and melt inclusions. [PDF]

, 2009
This study presents the work I have done during the 4 years of a PhD program that was part of the internationalization programme of the Italian research system approved by the Ministero della Ricerca e dell’Università (MIUR) between the Università degli ...
Esposito, Rosario
core   +1 more source

Continuous change monitoring of supraglacial lakes during melt and non-melt seasons with multi-source satellite imagery and deep learning

International Journal of Applied Earth Observations and Geoinformation
The surface melting of ice sheets is gradually intensifying with rising global temperatures. Supraglacial lakes (SGLs), an essential component of the ice-surface hydrological system, are significant for the ice sheet mass balance. SGLs have been shown to
Dongyu Zhu, Chunxia Zhou, Xiaoli Chen, Jiani Ouyang, Ce Zhang   +4 more
doaj   +1 more source

Geodynamic Models of Melt Generation and Extraction at Mid-Ocean Ridges [PDF]

Oceanography, 2012
It is widely accepted that plate divergence at mid-ocean ridges drives mantle flow, mantle melting, and the formation of new oceanic crust. However, many of the details of this process remain obscure because of the inaccessibility of the mantle to direct
Patricia M. Gregg, Laura B. Hebert, Laurent G.J. Montési, Richard F. Katz   +3 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The solubility and oxidation state of nickel in silicate melt at low oxygen fugacities: Results using a mechanically assisted equilibration technique [PDF]

, 1994
The solubility of Ni in a silicate melt has been measured using a new, mechanically assisted equilibration technique over a wide range of controlled ƒO2 values.
Spettel, Bernhard, Ertel, Werner, O'Neill, Hugh St. C., Dingwell, Donald B.   +3 more
core   +1 more source

Effect of annealing of ZnSe:Cr crystals in Bi(Zn) melt on the intensity of radiation bands of Cr ions

Moldavian Journal of the Physical Sciences, 2010
The photoluminescence in visible and near-IR spectral range of ZnSe:Cr as-grown and annealed in Bi(Zn) melt crystals was investigated at room temperature.
Culiuc, Leonid, Siminel, Anatolii, Nedeoglo, Dumitru, Suşchevici, Constantin   +3 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Melt densities in the Na2O-FeO-Fe2O3-SiO2 system and the partial molar volume of tetrahedrally-coordinated ferric iron in silicate melts [PDF]

, 1988
The densities of 12 melts in the Na2O-FeO-Fe2O3-SiO2 system have been determined in equilibrium with air, in the temperature range of 1000–1500°C, using the double bob, Archimedean technique.
Dickinson Jr., James E., Brearley, Mark, Dingwell, Donald B.   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source