Results 51 to 60 of about 920,485 (301)

The Meaning of Pressure for Primary Magmas: New Insights From PRIMELT3‐P

open access: yesGeochemistry, Geophysics, Geosystems, 2023
This paper reports new software, PRIMELT3‐P, for computing the pressure and temperature range over which a primary basaltic magma was formed by adiabatic decompression and fractional melting of fertile mantle peridotite.
Claude T. Herzberg   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Melt Collective : Circular Economy Innovation Lab

open access: yes, 2021
My thesis tells the story of of MELT Collective, a Circular Economy Innovation Lab at UBC. Here, complex recycling processes are distilled into a room with machines and tools that empower people to transform waste into something useful and beautiful ...
Chandrakesuma, Valerine
core  

Fabrication of Aluminum Alloy with Open-Channel and Columnar Structures through a Ceramic Fiber Template Method

open access: yesMetals, 2023
Aluminum alloys with open-channel and columnar structures were fabricated by casting the melt of aluminum alloys using a ceramic fiber template method. Stainless steel plates or wires coated with ceramic fibers impregnated by polyvinyl alcohol were used ...
Hideo Nakajima
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Effect of annealing of ZnSe:Cr crystals in Bi(Zn) melt on the intensity of radiation bands of Cr ions

open access: yesMoldavian Journal of the Physical Sciences, 2010
The photoluminescence in visible and near-IR spectral range of ZnSe:Cr as-grown and annealed in Bi(Zn) melt crystals was investigated at room temperature.
Culiuc, Leonid   +3 more
doaj  

Highly efficient Fe separation induced by Fe-containing particle agglomeration in Al-7Si-0.3Mg alloy melt

open access: yesJournal of Materials Research and Technology, 2022
In this paper, the melt turbulence process was introduced to result in Fe-containing particle agglomeration and achieve highly efficient Fe separation in Al-Si alloy melt. Microstructure analysis, 3D-morphology extraction, X-ray microscopy (μCT) analysis
Xiaozu Zhang   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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