Results 61 to 70 of about 128,718 (308)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of annealing of ZnSe:Cr crystals in Bi(Zn) melt on the intensity of radiation bands of Cr ions

Moldavian Journal of the Physical Sciences, 2010
The photoluminescence in visible and near-IR spectral range of ZnSe:Cr as-grown and annealed in Bi(Zn) melt crystals was investigated at room temperature.
Culiuc, Leonid, Siminel, Anatolii, Nedeoglo, Dumitru, Suşchevici, Constantin   +3 more
doaj  

Channelized melt flow in downwelling mantle: Implications for 226Ra-210Pb disequilibria in arc magmas [PDF]

, 2008
We present the results of an analytical model of porous flow of viscous melt into a steadily dilating ‘‘channel’’ (defined as a cluster of smaller veins) in downwelling subarc mantle.
Abelson, Aharonov, Asimow, Blundy, Bourdon, Brown, Cagnioncle, Conder, Davidson, Huang, Kelemen, M. A. Koenders, Maaloe, McKenzie, Murton, N. Petford, Plank, Ribe, Rubin, Rubin, Rushmer, S. Turner, Sleep, Spiegelman, Spiegelman, Spiegelman, Stevenson, Stracke, Stracke, Takahashi, Turner, Turner, Turner, Turner, Turner, van Keken, Walpole, Williams   +37 more
core   +1 more source

Mantle Melting and Melt Extraction Processes beneath Ocean Ridges: Evidence from Abyssal Peridotites [PDF]

Journal of Petrology, 1997
Abstract This paper presents the results of the first quantitative petrological modelling of abyssal peridotites. The mantle beneath a ridge may be considered as two regions: (1) the melting region between the solidus (Po) at which upwelling mantle begins to melt, and the depth (Pf) at which melting stops because of conductive cooling
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Penetrating keratoplasty using collagen crosslinked donor tissue: A case report

American Journal of Ophthalmology Case Reports, 2021
Purpose: In patients with corneal melt, pretreatment crosslinking (CXL) of donor tissue prior to placement of Boston keratoprosthesis (K-Pro I) decreases graft failure.
Sila Bal, Joseph B. Ciolino
doaj   +1 more source

ELASTIC-DISSIPATIVE STABILIZATION OF DYNAMIC PROCESSES OF HYDROPULSE SYSTEMS OF MINING MACHINES [PDF]

, 2018
Investigation of elastic-dissipative stabilization of dynamic processes of hydropulse systems of mining ...
SHEVCHUK, Stepan, SLIDENKO, Viktor
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Earth Mantle's Isotopic Record of Progressive Chemical Depletion

AGU Advances, 2023
Mid ocean ridge basalts are partial melts of mantle rocks that have become incompatible element depleted prior to recent sub‐ridge melting. This prior extent of melt extraction and concomitant incompatible element depletion is often inferred from the ...
C. Sani, A. Sanfilippo, A. A. Peyve, F. Genske, A. Stracke   +4 more
doaj   +1 more source

Rheology and Multiphase Flow in Congested Ammonia-Water-Ice Slurries [PDF]

, 2005
Cryomagmas are natural examples of complex multiphase fluids. Some preliminary statements are made about the rheology of densely packed suspensions that have important bearing on their flow rates and eruptive style.
Petford, Nick
core