Results 121 to 130 of about 1,482,837 (256)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Application of the Linkam TS1400XY heating stage to melt inclusion studies

Open Geosciences, 2012
Esposito Rosario, Klebesz Rita, Bartoli Omar, Klyukin Yury, Moncada Daniel, Doherty Angela, Bodnar Robert   +6 more
doaj   +1 more source

Melt inclusion constraints on petrogenesis of the 2014-2015 Holuhraun eruption, Iceland. [PDF]

Contrib Mineral Petrol, 2018
Hartley ME, Bali E, Maclennan J, Neave DA, Halldórsson SA.   +4 more
europepmc   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Small and large scale inhomogeneities in the magma chamber of the 18.6 ka Sarno plinian eruption of Mt Somma-Vesuvius (Italy) based on melt inclusion studies in nodules

, 2011
Description and petrography of plinian Sarno products of Mt Somma-Vesuvius.
KLEBESZ, RITA, DE VIVO, BENEDETTO, PETROSINO, PAOLA, LIMA, ANNAMARIA, BODNAR R. J.   +4 more
core  

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Sara Ho, Ziling Shen, Alexandria Lewis, Megha Patel, Anny Zheng, Gianna Proscino, Thaovy Ho, Jiangxia Wang, Marilyn Albert, Abhay Moghekar   +9 more
wiley   +1 more source

In-situ observation of inclusion agglomeration characteristics in high-manganese and high-aluminum steels with different Mn and Al contents

Materials & Design
Elucidating the agglomeration behavior of inclusions is critical for optimizing the quality of high-manganese and high-aluminum steels. This study predicted the precipitation behavior of inclusions using thermodynamic modeling.
Yuqing Yin, Wenjing Cheng, Yeguang Wang, Chengjun Liu, Maofa Jiang, Bo Zhang   +5 more
doaj   +1 more source

Crystallographically controlled alignment of melt inclusion entrapment in magmatic olivine: insights from lab-diffraction contrast tomography

Laboratory Diffraction Contrast Tomography (LabDCT) is a recent analytical development that allows for non-destructive microstructural characterisation of crystalline materials using a laboratory-scale X-ray microscope.
Ferguson, David, Macente, Alice, Boschetty, Felix, Trimby, Patrick, Douglas, Gareth, Thornhill, Helen   +5 more
core   +1 more source