Results 61 to 70 of about 1,482,837 (256)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

(Table S4) Trace element composition of matrix glasses and one melt inclusion as determined by LA-ICPMS

, 2018
(Table S4) Trace element composition of matrix glasses and one melt inclusion as determined by LA ...
Melanie Siegburg (6968786), Bach, Wolfgang, Rocholl, Alexander, Wolfgang Bach (6960488), Klügel, Andreas, Alexander Rocholl (5480873), Siegburg, Melanie, Andreas Klügel (6968789)   +7 more
core   +1 more source

Thermodynamic Modelling on Nanoscale Growth of Magnesia Inclusion in Fe-O-Mg Melt

Metals, 2019
Nano-magnesia is the intermediate product during the growth of magnesia inclusion in Mg-deoxidized steel. Understanding the thermodynamics on nano-magnesia is important to explore the relationship between magnesia product size and deoxidation reaction in
Yuanyou Xiao, Hong Lei, Bin Yang, Guocheng Wang, Qi Wang, Wei Jin   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Volatile emissions and magma storage conditions for the 2021 explosive eruption at La Soufrière volcano, St Vincent, from melt inclusions

Volcanica
The VEI 4 eruption of La Soufrière Volcano underwent a dramatic transition in style from initial lava dome effusion in December 2020 to hazardous explosive activity in April 2021.
TiVonne Howe, Thomas Christopher, Severine Moune, Hugh Tuffen, Paul Cole, Federica Schiavi   +5 more
doaj   +1 more source

A comparison of glacier melt on debris-covered glaciers in the northern and southern Caucasus [PDF]

, 2011
The glacier coverage in the Caucasus Mountains underwent considerable changes during the last decades. In some regions, the observed reduction in glacier area is comparable to those in the European Alps and the extent of supra-glacial debris increased on
W. Hagg, A. Lambrecht, Popovnin, V., Lambrecht, A., A. Rezepkin, Hagg, Wilfried, Svanadze, D., C. Mayer, Rezepkin, A., N. Lomidze, D. Svanadze, Lomidze, N., V. Popovnin, Mayer, C.   +13 more
core   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Ca/Al of plagioclase-hosted melt inclusions as an indicator for post-entrapment processes at mid-ocean ridges?

Geologica Acta, 2016
The composition of melt inclusions in basalts erupted at mid-ocean ridges may be modified by post-entrapment processes, so the present composition of melt inclusions may not represent their original composition at the time of entrapment. By combining the
H.T. ZHANG, Y.M. YANG, Q.-S. YAN, X.-F. SHI, Z.-W. ZHU, W.-C. SU, C.-J. QIN, J. YE   +7 more
doaj  

Arc distribution as a key driver of inclusion redistribution in Vacuum Arc Remelting (VAR)

Journal of Materials Research and Technology
A transient numerical model is developed to investigate inclusion transport and entrapment during full ingot growth in the Vacuum Arc Remelting (VAR) of the nickel-based superalloy GH4720Li. The model resolves the coupled electromagnetic field, melt-pool
Mehran Abdi, Ebrahim Karimi-Sibaki, Menghuai Wu, Jan Bohacek, Abdellah Kharicha   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source