Results 51 to 60 of about 1,482,837 (256)
Understanding magma genesis through analysis of melt inclusions: application of innovative micro-sampling techniques [PDF]
, 2007 Melt entrapped as inclusions in early-formed phenocrysts provide geochemists with an exceptional opportunity to study sample material from the earliest stages in the formation of a suite of lavas.
Harlou, Rikke
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Geochemistry, Geophysics, GeosystemsThe voluminous active volcanoes of the Revillagigedo Islands of Socorro and San Benedicto in the east Pacific Ocean exhibit hotspot geochemistry. However, the presence of a deep mantle plume has not been seismologically confirmed.
Janne M. Koornneef +7 more
doaj +1 more source
Sensitivity of a distributed temperature-radiation index melt model based on AWS observations and surface energy balance fluxes, Hurd Peninsula glaciers, Livingston Island, Antarctica [PDF]
, 2012 We use an automatic weather station and surface mass balance dataset spanning four melt seasons collected on Hurd Peninsula Glaciers, South Shetland Islands, to investigate the point surface energy balance, to determine the absolute and relative ...
Lapazaran Izargain, Javier Jesús +14 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Comparative Study of the Metallurgical Quality of Primary and Secondary AlSi10MnMg Aluminium Alloys
Metals, 2021 The use of secondary aluminium is increasingly being promoted in the automotive industry for environmental reasons. The purpose of this study was to demonstrate that it is possible to obtain a recycled AlSi10MnMg(Fe) aluminium alloy with equal ...
Asier Bakedano +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Geochemistry, Geophysics, Geosystems, 2020 Controlled cooling‐rate experiments were conducted on olivine‐hosted melt inclusions to characterize the development of compositional zoning observed in natural inclusions.
Lee M. Saper, Edward M. Stolper
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Case of Speech and Language Therapy – Inclusion Ireland [PDF]
, 2014 This short background paper prepared by and with Inclusion Ireland, offers a critical overview of the change process for services for children with disabilities through the microscope of one service: speech and language therapy.
Noone, Simon, Conroy, Pauline
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