Results 51 to 60 of about 1,420,609 (296)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Case of Speech and Language Therapy – Inclusion Ireland [PDF]

, 2014
This short background paper prepared by and with Inclusion Ireland, offers a critical overview of the change process for services for children with disabilities through the microscope of one service: speech and language therapy.
Noone, Simon, Conroy, Pauline
core  

Key New Evidence for the Hainan Mantle Plume Head: Ongoing Formation of a Large Igneous Province?

Geochemistry, Geophysics, Geosystems
The process‐based surface magmatic expression of mantle plumes is typically a large igneous province (LIP) induced by the mantle plume head, followed by subsequent age‐progressive volcanic tracks resulting from plate drifting above the plume tail ...
F. Yang, X. L. Huang, L. Liu, Y. G. Xu, Y. Hua, P. L. He, L. Zhang, W. F. Zhang, Y. Yu, H. Y. Li   +9 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Understanding magma genesis through analysis of melt inclusions: application of innovative micro-sampling techniques [PDF]

, 2007
Melt entrapped as inclusions in early-formed phenocrysts provide geochemists with an exceptional opportunity to study sample material from the earliest stages in the formation of a suite of lavas.
Harlou, Rikke
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Arc distribution as a key driver of inclusion redistribution in Vacuum Arc Remelting (VAR)

Journal of Materials Research and Technology
A transient numerical model is developed to investigate inclusion transport and entrapment during full ingot growth in the Vacuum Arc Remelting (VAR) of the nickel-based superalloy GH4720Li. The model resolves the coupled electromagnetic field, melt-pool
Mehran Abdi, Ebrahim Karimi-Sibaki, Menghuai Wu, Jan Bohacek, Abdellah Kharicha   +4 more
doaj   +1 more source

Controlled Cooling‐Rate Experiments on Olivine‐Hosted Melt Inclusions: Chemical Diffusion and Quantification of Eruptive Cooling Rates on Hawaii and Mars

Geochemistry, Geophysics, Geosystems, 2020
Controlled cooling‐rate experiments were conducted on olivine‐hosted melt inclusions to characterize the development of compositional zoning observed in natural inclusions.
Lee M. Saper, Edward M. Stolper
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

(Tabel S5b) Plagioclase-hosted melt inclusions, host plagioclase composition adjacent to inclusion, and thermobarometry of melt inclusion - host mineral pairs

, 2018
(Tabel S5b) Plagioclase-hosted melt inclusions, host plagioclase composition adjacent to inclusion, and thermobarometry of melt inclusion - host mineral ...
Melanie Siegburg (6968786), Bach, Wolfgang, Rocholl, Alexander, Wolfgang Bach (6960488), Klügel, Andreas, Alexander Rocholl (5480873), Siegburg, Melanie, Andreas Klügel (6968789)   +7 more
core   +1 more source