Results 91 to 100 of about 4,320,334 (318)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Membrane biofouling and scaling in forward osmosis membrane bioreactor

, 2012
The forward osmosis membrane bioreactor (FOMBR) has received much attention recently. Due to the high rejection nature of FO membranes, the biomass, dissolved organic and inorganic compounds retained in the bioreactor could cause membrane fouling by ...
Fane, Anthony Gordon, Lay, Winson Chee Loong, Tang, C, Wang, Rong, Chou, Shuren, Tang, Chuyang Y., Wang, R, Fane, AG, Loong, WLC, Zhang, J, Chou, S, Zhang, Jinsong   +11 more
core   +1 more source

The role of phospholipid molecular species in determining the physical properties of yeast membranes [PDF]

, 2018
In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane 'building blocks', glycerophospholipids play an important role in determining the physical ...
de Kroon, Anton I P M, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics, Renne, Mike F   +3 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Modeling of NF/RO membrane fouling and flux decline using real-time observations

, 2019
Many numerical models for membrane filtration have been developed to explain and predict fouling mechanisms. The models can simulate flux decline, transmembrane pressure increase, and fouling thickness based on theoretical equations.
Park, Sanghun, Park, Jongkwan, Baek, Sangsoo, Ligaray, Mayzonee, Jeong, Kwanho, Cho, Kyung Hwa, Chong, Tzyy Haur   +6 more
core   +1 more source

New Channelrhodopsin with a Red-Shifted Spectrum and Rapid Kinetics from Mesostigma viride

mBio, 2011
Light control of motility behavior (phototaxis and photophobic responses) in green flagellate algae is mediated by sensory rhodopsins homologous to phototaxis receptors and light-driven ion transporters in prokaryotic organisms. In the phototaxis process,
Elena G. Govorunova, Elena N. Spudich, C. Elizabeth Lane, Oleg A. Sineshchekov, John L. Spudich   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A tight polyethersulfone ultrafiltration membrane fabricated via polyion complex assisted phase inversion for dye desalination

, 2023
In this work, a tight polyethersulfone (PES) -based ultrafiltration (UF) membrane was fabricated to separate dye and salt of textile wastewater via a novel polyion complex assisted phase inversion method in one step.
Yali Zhao, Zhao, Yali, Gwo Sung Lai, Rong Wang, Wang, Rong, Yurong Yin, Lai, Gwo Sung, Yin, Yurong, Yuan Liao, Liao, Yuan   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source