Results 101 to 110 of about 5,362,504 (373)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

Nature Communications, 2019
Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby ...
Shruti Sharma, Antonio Carmona, Agnieszka Skowronek, Fangyan Yu, Mark O. Collins, Sindhu Naik, Claire M. Murzeau, Pei-Li Tseng, Kai S. Erdmann   +8 more
doaj   +1 more source

Role of Membrane GM1 on Early Neuronal Membrane Actions of Aβ During Onset of Alzheimer\u27s Disease [PDF]

, 2017
The ability of beta-amyloid peptide (Aβ) to disrupt the plasma membrane through formation of pores and membrane breakage has been previously described. However, the molecular determinants for these effects are largely unknown.
Aguayo, Luis G., Fernandez-Perez, E. J., Peoples, Robert W., Sepulveda, Fernando   +3 more
core   +1 more source

Diffusing proteins on a fluctuating membrane: Analytical theory and simulations

, 2010
Using analytical calculations and computer simulations we consider both the lateral diffusion of a membrane protein and the fluctuation spectrum of the membrane in which the protein is embedded.
B. Alberts, Ellen Reister-Gottfried, H. Lamb, H. Risken, Stefan M. Leitenberger, Udo Seifert   +5 more
core   +1 more source

Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]

, 2005
Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Bucciantini, Darkes, Duff, Ellis, Gilchrist, Harroun, Heller, Janson, Janson, Jeremy P. Bradshaw, Kelly, Kia Balali-Mood, Koebnik, Li, McIntosh, Mirzabekov, Richard H. Ashley, Rodrigues, Rodrigues, Stipani, Tenidis, Thomas Hauß, Tristram-Nagle, Walsh, Westermark, Wiener, Wigley, Wimley   +28 more
core   +1 more source

MEMBRANE-TO-MEMBRANE CROSS-BRIDGES [PDF]

The Journal of Cell Biology, 1971
No abstract ...
Franke, Werner W., Kartenbeck, Jürgen, Zentgraf, Hanswalter, Scheer, Ulrich, Falk, Heinz   +4 more
openaire   +4 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Quantum-measurement backaction from a Bose-Einstein condensate coupled to a mechanical oscillator [PDF]

, 2011
We study theoretically the dynamics of a hybrid optomechanical system consisting of a macroscopic mechanical membrane magnetically coupled to a spinor Bose-Einstein condensate via a nanomagnet attached at the membrane center.
Meystre, P., Schwab, K. C., Singh, S., Steinke, S. K., Tasgin, M. E., Vengalattore, M.   +5 more
core  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source