Results 211 to 220 of about 8,110,093 (383)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

COF Scaffold Membrane with Gate-Lane Nanostructure for Efficient Li⁺/Mg²⁺ Separation. [PDF]

Nanomicro Lett
Zhang Z, Kong Y, Li R, Yue X, Deng H, Zheng Y, Zhang S, Zhang R, Jiang Z.   +8 more
europepmc   +1 more source

A Family of Bacterial Cysteine Protease Type III Effectors Utilizes Acylation-dependent and -independent Strategies to Localize to Plasma Membranes [PDF]

, 2009
Robert H. Dowen, J Engel, Feng Shao, Joseph R. Ecker, Jack E. Dixon   +4 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Resilient high-temperature reverse osmosis desalination membranes. [PDF]

Sci Adv
Wu J, Xiao M, He J, Tang R, Soares K, Hou Z, Wang X, Jassby D, Elimelech M, Hoek EMV.   +9 more
europepmc   +1 more source

Mixed-matrix carbon molecular sieve membranes using hierarchical zeolite: A simple approach towards high CO2 permeability enhancements

, 2019
Wen Li, Kunli Goh, Chong Yang Chuah, Tae‐Hyun Bae   +3 more
openalex   +1 more source

Pulse EPR Detection of Lipid Exchange between Protein-Rich Raft and Bulk Domains in the Membrane: Methodology Development and Its Application to Studies of Influenza Viral Membrane [PDF]

, 2001
Kazunori Kawasaki, Jun‐Jie Yin, Witold K. Subczynski, James S. Hyde, Akihiro Kusumi   +4 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Electric field-induced rupture kinetics of giant unilamellar vesicles with varying gramicidin A content in membrane. [PDF]

PLoS One
Bhuiyan MTI, Ahamed MJ, Sultana R, Nasrin T, Ahamed MK, Billah MM, Karal MAS.   +6 more
europepmc   +1 more source

Monte Carlo study of the frame, fluctuation and internal tensions of fluctuating membranes with fixed area

, 2016
Hayato Shiba, Hiroshi Noguchi, Jean‐Baptiste Fournier   +2 more
openalex   +2 more sources