Results 101 to 110 of about 116,413 (235)

Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae

mBio
The complement cascade is a front-line defense against pathogens. Complement activation generates the membrane attack complex (MAC), a 10–11 nm diameter pore formed by complement proteins C5b through C8 and polymerized C9. The MAC embeds within the outer
Evan R. Lamb, Alison K. Criss
doaj   +1 more source

Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages. [PDF]

Front Immunol, 2022
Jimenez-Duran G, Kozole J, Peltier-Heap R, Dickinson ER, Kwiatkowski CR, Zappacosta F, Annan RS, Galwey NW, Nichols EM, Modis LK, Triantafilou M, Triantafilou K, Booty LM.   +12 more
europepmc   +1 more source

Intracrystalline Void‐Mediated Toughening of Brittle Crystals in Quail Eggshells

Advanced Functional Materials, EarlyView.
In quail eggshells, the high density and disordered arrangement of intracrystalline voids inhibit lattice cleavage, suppress long‐range crack propagation, and promote deformation twinning and quasi‐plasticity, serving as an essential toughening motif. We show that these voids remain within a narrow subcritical size range and therefore predominantly do ...
Jingxiao Zhong, Qihang Wang, Andre E. Vellwock, Sinuhe Perea Puente, Tingting Zhu, Jia Hui Lim, Kadda Medjoubi, Sebastian Hoerl, Erika Griesshaber, Wolfgang W. Schmahl, Yannicke Dauphin, Emeline Raguin, Peter Werner, Francesco Stellacci, Michael V. Swain, Peter Fratzl, Shahrouz Amini   +16 more
wiley   +1 more source

Correction: Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores. [PDF]

PLoS Pathog, 2022
Doorduijn DJ, Heesterbeek DAC, Ruyken M, de Haas CJC, Stapels DAC, Aerts PC, Rooijakkers SHM, Bardoel BW.   +7 more
europepmc   +1 more source

Utilizing the Metastability of Spidroins as a Strategy for Improving Mechanical Properties of Biomimetic Spider Silk Fibers

Advanced Functional Materials, EarlyView.
Phase transitions are central for the assembly of recombinant silk proteins into fibers. Soluble protein can transition into condensed states such as condensates and gels. These states are metastable and evolve in a time‐dependent way. Metastability depends on the protein sequence, and this relationship can be used to enhance the mechanical properties ...
Fred‐Eric Sammalisto, Topias Lankinen, Celine Tallroth, Rafael A. Lara, Matilda Backholm, Markus B. Linder   +5 more
wiley   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Regulatory gene network for coffee-like color morph of TYRP1 mutant of oujiang color common carp

BMC Genomics
Background Neither a TYRP1-mediated highly conserved genetic network underlying skin color towards optimum defense nor the pathological tendency of its mutation is well understood. The Oujiang Color Common Carp (Cyprinus carpio var.
Roland Nathan Mandal, Jing Ke, Nusrat Hasan Kanika, Fuyan Wang, Jun Wang, Chenghui Wang   +5 more
doaj   +1 more source

C5b-9 Membrane Attack Complex Formation and Extracellular Vesicle Shedding in Barrett's Esophagus and Esophageal Adenocarcinoma. [PDF]

Front Immunol, 2022
Kolka CM, Webster J, Lepletier A, Winterford C, Brown I, Richards RS, Zelek WM, Cao Y, Khamis R, Khamis R, Shanmugasundaram KB, Wuethrich A, Trau M, Brosda S, Barbour A, Shah AK, Eslick GD, Clemons NJ, Morgan BP, Hill MM.   +19 more
europepmc   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex. [PDF]

J Innate Immun, 2023
Gytz Olesen H, Michailidou I, Zelek WM, Vreijling J, Ruizendaal P, de Klein F, Marquart JA, Kuipers TB, Mei H, Zhang Y, Ahasan M, Johnson KK, Wang Y, Morgan BP, van Dijk M, Fluiter K, Andersen GR, Baas F.   +17 more
europepmc   +1 more source