Results 11 to 20 of about 165,835 (261)
On Gaussian curvature and membrane fission [PDF]
Scientific Reports, 2021 We propose a three-dimensional mathematical model to describe dynamical processes of membrane fission. The model is based on a phase field equation that includes the Gaussian curvature contribution to the bending energy. With the addition of the Gaussian
Mara Denisse Rueda-Contreras +4 more
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Mechanisms of Membrane Curvature Generation in Membrane Traffic [PDF]
Membranes, 2012 During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps.
Hye-Won Shin +2 more
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Modeling Membrane Curvature Generation due to Membrane–Protein Interactions [PDF]
Biomolecules, 2018 To alter and adjust the shape of the plasma membrane, cells harness various mechanisms of curvature generation. Many of these curvature generation mechanisms rely on the interactions between peripheral membrane proteins, integral membrane proteins, and ...
Haleh Alimohamadi, Padmini Rangamani
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Clathrin senses membrane curvature. [PDF]
Biophys J, 2021 ABSTRACTThe ability of proteins to sense membrane curvature is essential to diverse membrane remodeling processes including clathrin-mediated endocytosis. Multiple adaptor proteins within the clathrin pathway have been shown to assemble together at curved membrane sites, leading to local recruitment of the clathrin coat.
Zeno WF +7 more
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Sensing Membrane Curvature [PDF]
Developmental Cell, 2003 AbstractTransport vesicle formation and fusion are highly regulated processes that require the sequential assembly and disassembly of proteinacious membrane coats. Recent work suggests that one of the coat proteins senses the local changes in lipid packing that accompany membrane bending during vesiculation, and thus acts as a timer for coat ...
Holthuis, J.C.M., Burger, K.N.J.
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Sensing membrane stresses by protein insertions. [PDF]
PLoS Computational Biology, 2014 Protein domains shallowly inserting into the membrane matrix are ubiquitous in peripheral membrane proteins involved in various processes of intracellular membrane shaping and remodeling.
Felix Campelo, Michael M Kozlov
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Membrane curvature in flaviviruses [PDF]
Journal of Structural Biology, 2013 Coordinated interplay between membrane proteins and the lipid bilayer is required for such processes as transporter function and the entrance of enveloped viruses into host cells. In this study, three-dimensional cryo-electron microscopy density maps of mature and immature flaviviruses were analyzed to assess the curvature of the membrane leaflets and ...
Wei, Zhang +4 more
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Membrane curvature induces cardiolipin sorting [PDF]
Communications Biology, 2019 AbstractCardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of bacteria and in the mitochondrial cristae. This specific localization has been argued to be geometry-driven, since the CL’s conical shape relaxes curvature frustration. Although previous evidence suggests a coupling between CL concentration and membrane shape
Elena Beltrán-Heredia +5 more
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Membrane Curvature Catalyzes Lipid Droplet Assembly [PDF]
Current Biology, 2020 Lipid droplet (LD) biogenesis begins in the endoplasmic reticulum (ER) bilayer, but how the ER topology impacts this process is unclear. An early step in LD formation is nucleation, wherein free neutral lipids, mainly triacylglycerols (TGs) and sterol esters (SEs), condense into a nascent LD. How this transition occurs is poorly known.
Santinho, Alexandre +7 more
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Membrane curvature at a glance [PDF]
Journal of Cell Science, 2015 ABSTRACT Membrane curvature is an important parameter in defining the morphology of cells, organelles and local membrane subdomains. Transport intermediates have simpler shapes, being either spheres or tubules. The generation and maintenance of curvature is of central importance for maintaining trafficking and cellular functions.
McMahon, HT, Boucrot, E
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