Results 11 to 20 of about 69,381 (252)
On Gaussian curvature and membrane fission [PDF]
Scientific Reports, 2021 We propose a three-dimensional mathematical model to describe dynamical processes of membrane fission. The model is based on a phase field equation that includes the Gaussian curvature contribution to the bending energy. With the addition of the Gaussian
Mara Denisse Rueda-Contreras +4 more
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Mechanisms of Membrane Curvature Generation in Membrane Traffic [PDF]
Membranes, 2012 During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps.
Hye-Won Shin +2 more
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Clathrin Senses Membrane Curvature [PDF]
Biophysical Journal, 2020 ABSTRACT The ability of proteins to sense membrane curvature is essential to diverse membrane remodeling processes including clathrin-mediated endocytosis. Multiple adaptor proteins within the clathrin pathway have been shown to assemble together at curved membrane sites, leading to local recruitment of the clathrin coat.
Wade F, Zeno +7 more
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Sensing Membrane Curvature [PDF]
Developmental Cell, 2003 AbstractTransport vesicle formation and fusion are highly regulated processes that require the sequential assembly and disassembly of proteinacious membrane coats. Recent work suggests that one of the coat proteins senses the local changes in lipid packing that accompany membrane bending during vesiculation, and thus acts as a timer for coat ...
Holthuis, J.C.M., Burger, K.N.J.
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Membrane curvature in flaviviruses [PDF]
Journal of Structural Biology, 2013 Coordinated interplay between membrane proteins and the lipid bilayer is required for such processes as transporter function and the entrance of enveloped viruses into host cells. In this study, three-dimensional cryo-electron microscopy density maps of mature and immature flaviviruses were analyzed to assess the curvature of the membrane leaflets and ...
Wei, Zhang +4 more
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Membrane curvature at a glance [PDF]
Journal of Cell Science, 2015 ABSTRACT Membrane curvature is an important parameter in defining the morphology of cells, organelles and local membrane subdomains. Transport intermediates have simpler shapes, being either spheres or tubules. The generation and maintenance of curvature is of central importance for maintaining trafficking and cellular functions.
McMahon, HT, Boucrot, E
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Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx. [PDF]
Proc Natl Acad Sci U S AGeneration of membrane curvature is fundamental to cellular function. Recent studies have established that the glycocalyx, a sugar-rich polymer layer at the cell surface, can generate membrane curvature. While there have been some theoretical efforts to understand the interplay between the glycocalyx and membrane bending, there remain open questions ...
Xiao K +3 more
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Mechanism of membrane-curvature generation by ER-tubule shaping proteins
Nature Communications, 2021 The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood.
Ning Wang +5 more
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Membrane curvature response in autophagy [PDF]
Autophagy, 2011 Membrane trafficking is key for signal transduction, cargo transportation, and in the case of autophagy, delivering cytoplasmic substrates to the lysosome for degradation. Autophagy requires the formation of a unique double membrane vesicle, the autophagosome. However, the mechanism by which the autophagosome forms is unknown.
Livia, Wilz, Weiliang, Fan, Qing, Zhong
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Sensing Membrane Curvature in Macroautophagy [PDF]
Journal of Molecular Biology, 2017 In response to intracellular stress events ranging from starvation to pathogen invasion, the cell activates one or more forms of macroautophagy. The key event in these related pathways is the de novo formation of a new organelle called the autophagosome, which either surrounds and sequesters random portions of the cytoplasm or selectively targets ...
Nathan, Nguyen +2 more
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