Results 71 to 80 of about 165,835 (261)
Models for membrane curvature sensing of curvature generating proteins [PDF]
Pramana, 2020 13 pages, 3 ...
T V Sachin Krishnan +2 more
openaire +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Extracellular domain 2 of TSPAN4 governs its functions
Biophysical ReportsTetraspanin 4, a protein with four transmembrane helices and three connecting loops, senses membrane curvature and localizes to membrane tubes. This enrichment in tubular membranes enhances its diverse interactions.
Raviv Dharan, Alisa Vaknin, Raya Sorkin
doaj +1 more source
Spinor representation of surfaces and complex stresses on membranes and interfaces
, 2011 Variational principles are developed within the framework of a spinor representation of the surface geometry to examine the equilibrium properties of a membrane or interface. This is a far-reaching generalization of the Weierstrass-Enneper representation
A. Gray +11 more
core +1 more source
Curvature-Driven Molecular Flow on Membrane Surface [PDF]
SIAM Journal on Applied Mathematics, 2017 Morphological change of bilayer membrane in vivo is not a spontaneous procedure but modulated by various types of proteins in general. Most of these modulations are associated with the localization of related proteins in the crowded lipid environment in bilayer membrane.
Mikucki, Michael, Zhou, Y. C.
openaire +3 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Coupling between Lipid Shape and Membrane Curvature [PDF]
Biophysical Journal, 2006 Using molecular dynamics simulations, we examine the behavior of lipids whose preferred curvature can be systematically varied. This curvature is imposed by controlling the headgroup size of a coarse-grained lipid model recently developed by us. To validate this approach, we examine self-assembly of each individual lipid type and observe the complete ...
Cooke, I., Deserno, M.
openaire +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Surface Polymer Network Model and Effective Membrane Curvature Elasticity
, 1995 A microscopic model of a surface polymer network - membrane system is introduced, with contact polymer surface interactions that can be either repulsive or attractive and sliplinks of functionality four randomly distributed over the supporting membrane ...
B. Duplantier +19 more
core +1 more source