Results 71 to 80 of about 1,339,571 (248)

FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria.

PLoS Biology, 2021
Little is known about mechanisms of membrane fission in bacteria despite their requirement for cytokinesis. The only known dedicated membrane fission machinery in bacteria, fission protein B (FisB), is expressed during sporulation in Bacillus subtilis ...
Ane Landajuela, Martha Braun, Christopher D A Rodrigues, Alejandro Martínez-Calvo, Thierry Doan, Florian Horenkamp, Anna Andronicos, Vladimir Shteyn, Nathan D Williams, Chenxiang Lin, Ned S Wingreen, David Z Rudner, Erdem Karatekin   +12 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Membrane fouling in osmotically driven membrane processes: A review

, 2016
The utilization of osmosis for engineered applications sparked off various emerging technologies relying on osmotically driven membrane processes (ODMPs).
Fane, Anthony Gordon, Tang, C, She, Q, Wang, Rong, She, Qianhong, Tang, Chuyang Y., Wang, R, Fane, AG   +7 more
core   +1 more source

Modeling and computation of two phase geometric biomembranes using surface finite elements [PDF]

, 2010
Biomembranes consisting of multiple lipids may involve phase separation phenomena leading to coexisting domains of different lipid compositions.
Stinner, Björn, Elliott, Charles M.
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing

Nature Communications, 2018
Many proteins which sense membrane curvature contain intrinsically disordered domains. Here the authors use Monte Carlo simulations combined with experimental approaches and report that disordered domains are potent sensors of membrane curvature.
Wade F. Zeno, Upayan Baul, Wilton T. Snead, Andre C. M. DeGroot, Liping Wang, Eileen M. Lafer, D. Thirumalai, Jeanne C. Stachowiak   +7 more
doaj   +1 more source

Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface. [PDF]

PLoS ONE, 2012
The different pathways of endocytosis share an initial step involving local inward curvature of the cell's lipid bilayer. It has been shown that to generate membrane curvature, proteins or lipids enforce transversal asymmetry of the plasma membrane. Thus
Nadav Ben-Dov, Rafi Korenstein
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells

Nature Communications
Positive-sense RNA viruses, including SARS-CoV-1 and -2, DENV, and CHIKV, replicate in curved membrane compartments within host cells. Non-structural proteins (nsPs) critically regulate these nanoscale membrane structures, yet their curvature-dependent ...
Xinwen Miao, Michelle Cheok Yien Law, Jatin Kumar, Choon-Peng Chng, Yongpeng Zeng, Yaw Bia Tan, Jiawei Wu, Xiangfu Guo, Lizhen Huang, Yinyin Zhuang, Weibo Gao, Changjin Huang, Dahai Luo, Wenting Zhao   +13 more
doaj   +1 more source