Spatial regulation of membrane fusion controlled by modification of phosphoinositides. [PDF]
PLoS ONE, 2010 Membrane fusion plays a central role in many cell processes from vesicular transport to nuclear envelope reconstitution at mitosis but the mechanisms that underlie fusion of natural membranes are not well understood.
Fabrice Dumas +5 more
doaj +1 more source
Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1. [PDF]
, 2020 The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood.
Hu, Junjie +13 more
core
Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism [PDF]
, 2018 Environmental stressors like ethanol (EtOH) commonly target mitochondria to influence the cell’s fate. Recent literature supports that chronic EtOH exposure suppresses mitochondrial dynamics, central to quality control, and sensitizes mitochondrial ...
Hajnóczky, György +4 more
core +3 more sources
Fusogenic structural changes in arenavirus glycoproteins are associated with viroporin activity.
PLoS Pathogens, 2023 Many enveloped viruses enter host cells by fusing with acidic endosomes. The fusion activity of multiple viral envelope glycoproteins does not generally affect viral membrane permeability.
You Zhang +4 more
doaj +1 more source
Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion [PDF]
, 2015 Intra-endolysosomal Ca(2+) release is required for endolysosomal membrane fusion with intracellular organelles. However, the molecular mechanisms for intra-endolysosomal Ca(2+) release and the downstream Ca(2+) targets involved in the fusion remain ...
Baars +70 more
core +1 more source
Influenza Virus-cell Fusion Inhibition Assay
Bio-Protocol, 2013 During viral infection to host cells, several viruses undergo the process of endocytosis and pH-dependent fusion. By fusion of viral membrane with host cellular membrane, the viral core invades to host cytoplasm.
Mayo Yasugi, Kazuyoshi Ikuta
doaj +1 more source
Advanced Science, 2023 The receptor‐binding domain (RBD) of spike recognizing the receptor angiotensin‐converting enzyme 2 (ACE2) initiates membrane fusion between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and cell membrane.
Mengdan Wu +13 more
doaj +1 more source
Structural Insights into Membrane Fusion Mediated by Convergent Small Fusogens
Cells, 2021 From lifeless viral particles to complex multicellular organisms, membrane fusion is inarguably the important fundamental biological phenomena. Sitting at the heart of membrane fusion are protein mediators known as fusogens.
Yiming Yang, Nandini Nagarajan Margam
doaj +1 more source
Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]
, 1996 Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD +5 more
core +2 more sources
Epigallocatechin gallate inhibits SNARE‐dependent membrane fusion by blocking trans‐SNARE assembly
FEBS Open Bio, 2022 Insulin secretion is a signal‐triggered process that requires membrane fusion between the secretory granules and plasma membrane in pancreatic β cells. The exocytosis of insulin is mediated by target‐soluble N‐ethylmaleimide sensitive factor attachment ...
Min Zhu +4 more
doaj +1 more source