Results 251 to 260 of about 2,350,953 (316)
Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin +11 more
wiley +1 more source
Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, EarlyView.Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
Protein mannosylation in actinobacteria an enigmatic post-translational modification. [PDF]
RSC Chem BiolKing CB, Wakarchuk WW.
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Advances and challenges in plant N-glycoengineering: when fucosylation matters. [PDF]
Front Plant SciGauba K, Kunnummel V, Castilho A.
europepmc +1 more source
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
Oropouche virus: molecular virological characteristics and research progress of a neglected arbovirus. [PDF]
Virol JLin S, Wang Q, Wang C, Liu Q.
europepmc +1 more source
Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis
BMEMat, EarlyView.This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang +6 more
wiley +1 more source
CD147 at the crossroads of glycoprotein networks, metabolic reprogramming, and metastatic progression. [PDF]
Front ImmunolSu TS, Wang JW, Su YL, Lin MH, Chiou HC.
europepmc +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source