Results 251 to 260 of about 2,327,252 (364)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Dual roles of <i>Anisakis pegreffii</i> proteins in macrophage immune dynamics. [PDF]

Front Immunol
Zeng MH, Alsobaie S, Wang XX, Li S, Aldakheel FM, Aboul-Soud MAM, Liu WB.   +6 more
europepmc   +1 more source

Membrane glycoprotein synthesis: cleavage of the signal sequence in the absence of glycosylation [PDF]

, 1982
Robert A. Irving, Theo Hofmann, Hara P. Ghosh   +2 more
openalex   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity. [PDF]

Proc Natl Acad Sci U S A
Bentley K, Statkute E, Murrell I, Fielding CA, Antrobus R, Preston H, Kerr-Jones L, Cochrane D, Brizic I, Lehner PJ, Wilkinson GWG, Wang ECY, Graham SC, Weekes MP, Stanton RJ.   +14 more
europepmc   +1 more source

Determination of the orientation of an integral membrane protein and sites of glycosylation by oligonucleotide-directed mutagenesis: influenza B virus NB glycoprotein lacks a cleavable signal sequence and has an extracellular NH2-terminal region.

, 1986
Mark A. Williams, Robert A. Lamb
openalex   +1 more source

Isolation and structural characterization of the polypeptide subunits of membrane glycoprotein IIb-IIIa from human platelets [PDF]

, 1982
RP McEver, JU Baenziger, PW Majerus
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Optimization of the VSV-G backbone for amino terminal fusion with nanobodies allowing its specific retargeting to HER2 receptors. [PDF]

Mol Ther Oncol
Duquénois I, Thébault S, Johari S, Raux H, Ouldali M, Moutel S, Lagaudrière-Gesbert C, Perez F, Albertini AA, Gaudin Y.   +9 more
europepmc   +1 more source

Biogenesis of plasma membrane glycoproteins. Purification and properties of two rat liver plasma membrane glycoproteins.

, 1980
John Elovson
openalex   +1 more source