Results 21 to 30 of about 133,090 (338)

Neutrophil azurophilic granule glycoproteins are distinctively decorated by atypical pauci- and phosphomannose glycans

Communications Biology, 2021
Reiding et al. performed conventional proteomics as well as glycoproteomics on protein extracts from lysates of pooled neutrophils obtained from ten healthy donors.
Karli R. Reiding, Yu-Hsien Lin, Floris P. J. van Alphen, Alexander B. Meijer, Albert J. R. Heck   +4 more
doaj   +1 more source

Fluorescent Staining of Glycoproteins on Polyvinylidene Difluoride Membrane with 8-Aminonaphthalene-1,3,6-Trisulfonate

BioTechniques, 2001
Here, we describe a simple and sensitive method that allows fluorescent detection of glycoproteins on polyvinylidene difluoride (PVDF) membrane. We used periodic acid oxidation of carbohydrate chains of glycoproteins and fluorescent labeling with 8 ...
F.Y. Che, J.F. Song, L.R. Yu, K.Y. Wang, Q.C. Xia   +4 more
doaj   +1 more source

Human galectin-1 and galectin-3 promote Tropheryma whipplei infection

Gut Microbes, 2021
Tropheryma whipplei, is an actinobacterium that causes different infections in humans, including Whipple’s disease. The bacterium infects and replicates in macrophages, leading to a Th2-biased immune response. Previous studies have shown that T. whipplei
Diyoly Ayona, Sandra Madariaga Zarza, Ludovic Landemarre, Benoît Roubinet, Philippe Decloquement, Didier Raoult, Pierre-Edouard Fournier, Benoit Desnues   +7 more
doaj   +1 more source

Lipidomimetic Compounds Act as HIV-1 Entry Inhibitors by Altering Viral Membrane Structure

Frontiers in Immunology, 2018
The envelope of Human Immunodeficiency Virus type 1 (HIV-1) consists of a liquid-ordered membrane enriched in raft lipids and containing the viral glycoproteins.
Jon Ander Nieto-Garai, Bärbel Glass, Carmen Bunn, Matthias Giese, Gary Jennings, Beate Brankatschk, Beate Brankatschk, Sameer Agarwal, Sameer Agarwal, Kathleen Börner, F. Xabier Contreras, F. Xabier Contreras, Hans-Joachim Knölker, Hans-Joachim Knölker, Claudia Zankl, Claudia Zankl, Kai Simons, Cornelia Schroeder, Cornelia Schroeder, Cornelia Schroeder, Maier Lorizate, Hans-Georg Kräusslich   +21 more
doaj   +1 more source

Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage

Emerging Microbes and Infections, 2023
Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-
Changqing Yu, Guosheng Wang, Qiang Liu, Jingbo Zhai, Mengzhou Xue, Qiang Li, Yuanhua Xian, Chunfu Zheng   +7 more
doaj   +1 more source

Combining detection and reconstruction of correlational and quasi-periodic motifs in viral genomic sequences with transitional genome mapping: Application to COVID-19 [PDF]

Journal of Integrated OMICS, 2021, v.11(1) p.5-11, 2020
A method of Transitional Automorphic Mapping of the Genome on Itself (TAMGI) is aimed at combining detection and reconstruction of correlational and quasi-periodic motifs in the viral genomic RNA/DNA sequences. The motifs reconstructed by TAMGI are robust with respect to indels and point mutations and can be tried as putative therapeutic targets.
arxiv   +1 more source

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment. [PDF]

PLoS Pathogens, 2016
Receptor-targeted lentiviral vectors (LVs) can be an effective tool for selective transfer of genes into distinct cell types of choice. Moreover, they can be used to determine the molecular properties that cell surface proteins must fulfill to act as ...
Ruben R Bender, Anke Muth, Irene C Schneider, Thorsten Friedel, Jessica Hartmann, Andreas Plückthun, Andrea Maisner, Christian J Buchholz   +7 more
doaj   +1 more source

Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity

Viruses, 2021
Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells.
William E. Diehl, Mehmet H. Guney, Teresa Vanzo, Pyae P. Kyawe, Judith M. White, Massimo Pizzato, Jeremy Luban   +6 more
doaj   +1 more source

A potent subset of Mycobacterium tuberculosis glycoproteins as relevant candidates for vaccine and therapeutic target

Scientific Reports, 2023
Tuberculosis (TB) remains one of the most afflictive bacterial infections globally. In high burden TB countries, surveillance, diagnosis and treatment of drug resistant TB (RR and X/MDRTB) display a crucial public health challenge. Therefore, we need new
Shamsi Yari, Parviz Afrough, Fatemeh Yari, Morteza Ghazanfari Jajin, Abolfazl Fateh, Alireza Hadizadeh Tasbiti   +5 more
doaj   +1 more source

Mechanisms of receptor/coreceptor-mediated entry of enveloped viruses [PDF]

Biophysical Journal, 96, 2624-2636, (2009), 2008
Enveloped viruses enter host cells either through endocytosis, or by direct fusion of the viral membrane envelope and the membrane of the host cell. However, some viruses, such as HIV-1, HSV-1, and Epstein-Barr can enter a cell through either mechanism, with the choice of pathway often a function of the ambient physical chemical conditions, such as ...
arxiv   +1 more source