Results 171 to 180 of about 2,473,220 (258)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment. [PDF]

J Lipid Res, 2015
Steil D, Schepers CL, Pohlentz G, Legros N, Runde J, Humpf HU, Karch H, Müthing J.   +7 more
europepmc   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Intramuscular neutrophil‐derived immunometabolic niches locally boost insulin‐responsive GLUT4 translocation after muscle contraction

The Journal of Physiology, EarlyView.
Abstract figure legend Contraction‐induced formation of a NET‐based immunometabolic niche potentiates regional insulin sensitivity and GLUT4 translocation. The schematic model illustrating how skeletal muscle contraction promotes a NET‐based immunometabolic niche that enhances regional insulin sensitivity.
Weijian Chen, Makoto Kanzaki
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Endothelium‐dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium‐derived ...
Nathan M. Luque, Leo Leader, Sandra M. Lowe, Steven D. Horrowitz, Marianne Tare, Victoria Hinkley, Vladimir V. Matchkov, Maged M. Costantine, Irit Markus, Lu Liu, Shaun L. Sandow, Timothy V. Murphy   +11 more
wiley   +1 more source

Targeting Cellular Lipid Rafts for Dynamic Nuclear Polarization Nuclear Magnetic Resonance

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Illuminating lipid rafts within intact cells using dynamic nuclear polarization (DNP). Targeting lipid rafts with the protein ostreolysin A allows the selective delivery of DNP‐compatible radicals, generating hyperpolarization of nuclear spins in the lipid raft. Lipid rafts serve as important platforms for membrane and signaling proteins.
Sarah A. Overall, Agnes Eck, Ancy T. Wilson, Dorothea Pinotsi, Sina J. Hartmann, Katja Packebusch, Snorri Th. Sigurdsson, Alexander B. Barnes   +7 more
wiley   +1 more source