Results 191 to 200 of about 2,473,220 (258)
ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 2, March 2026.This review focuses on the mechanisms of Zn2+ electrodeposition and interfacial failure together with systematical artificial interphase layer design strategies from carbon materials, zincophilic alloys, to inorganic/organic compound layers, regulating ion flux and desolvation and providing guidance for programmable interface construction in aqueous ...
Bixian Chen +12 more
wiley +1 more source
Ciliary Defects in Inherited Retinal Diseases
Advanced Genetics, Volume 7, Issue 1, March 2026.The photoreceptor cilium is a specialized sensory organelle essential for vision. This review systematically summarizes the structural and functional defects of the cilium that lead to inherited retinal diseases (IRDs). It highlights key pathogenic genes, elucidates molecular mechanisms of degeneration, and evaluates emerging therapeutic strategies ...
Guizhi Guo, Lin Li, Jun Zhou, Jie Ran
wiley +1 more source
LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases
MedComm, Volume 7, Issue 3, March 2026.The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1986 B. Satir, M. Reichman, E. Orias
semanticscholar +1 more source
Heart Failure: Epidemiology, Pathophysiology, and Management
MedComm, Volume 7, Issue 3, March 2026.This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan +9 more
wiley +1 more source
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities
MedComm, Volume 7, Issue 3, March 2026.Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou +5 more
wiley +1 more source
MedComm, Volume 7, Issue 3, March 2026.Simple incubation with DP7‐C enables the generation of extracellular vesicles (DP‐EVs) with enhanced both tumor and lymph nodes targeting properties. DP‐EVs/siPD‐L1 can effectively inhibit tumor growth and greatly prolong the survival of tumor bearing mice through immune response activation and tumor microenvironment reprogramming.
Yusi Wang +8 more
wiley +1 more source
Membrane domains as new drug targets
Frontiers in Physiology, 2015 Annemiek B van Spriel +2 more
doaj +1 more source
Membrane microdomains are crucial for <i>Mycobacterium marinum</i> EsxA-dependent membrane damage, escape to the cytosol, and infection. [PDF]
Sci AdvPerret A +7 more
europepmc +1 more source
Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source