Results 1 to 10 of about 642,713 (354)

Cyclic peptide membrane permeability prediction using deep learning model based on molecular attention transformer [PDF]

Frontiers in Bioinformatics
Membrane permeability is a critical bottleneck in the development of cyclic peptide drugs. Experimental membrane permeability testing is costly, and precise in silico prediction tools are scarce.
Dawei Jiang, Zixi Chen, Zixi Chen, Hongli Du   +3 more
doaj   +2 more sources

ULTRASTRUCTURE AND PERMEABILITY OF NUCLEAR MEMBRANES [PDF]

The Journal of Cell Biology, 1965
The fine structures of nuclear envelopes known to have different permeability properties were compared. Membranes of salivary gland cell nuclei of Drosophila (third instar) and Chironomus (prepupae), which are strong barriers to ion diffusion, and membranes of oocyte nuclei (germinal vesicle) of Xenopus and Triturus, which are much more ion-permeable ...
Joseph Wiener, David Spiro, Werner R. Loewenstein   +2 more
openalex   +4 more sources

Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability [PDF]

Animal, 2011
In the meat industry, the manipulation of fat deposition in cattle is of pivotal importance to improve production efficiency, carcass composition and ultimately meat quality.
A.P. Martins, P.A. Lopes, A.S.H. Costa, S.V. Martins, N.C. Santos, J.A.M. Prates, T.F. Moura, G. Soveral   +7 more
doaj   +3 more sources

Study of effective parameters on the transport of dysprosium through a supported liquid membrane containing Cyanex 272 as a carrier [PDF]

مجله علوم و فنون هسته‌ای, 2022
In this study, the extraction of dysprosium was investigated using a supported liquid membrane (SLM) system. The experiments were performed using bis (2, 4, and 4-trimethylpentyl) phosphinic acid (Cyanex272) as the carrier.
F. Zahakifar, P. Zaheri, M. Ghanadi Maragheh   +2 more
doaj   +1 more source

Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides

Nature Communications, 2023
Naturally occurring peptides with high membrane permeability often have backbone ester bonds. Here, the authors investigated the effect of an amide-to-ester substitution on membrane permeability of peptides and found the substitution is useful for ...
Yuki Hosono, Satoshi Uchida, Moe Shinkai, Chad E. Townsend, Colin N. Kelly, Matthew R. Naylor, Hsiau-Wei Lee, Kayoko Kanamitsu, Mayumi Ishii, Ryosuke Ueki, Takumi Ueda, Koh Takeuchi, Masatake Sugita, Yutaka Akiyama, Scott R. Lokey, Jumpei Morimoto, Shinsuke Sando   +16 more
doaj   +1 more source

CO2 permeability of the rat erythrocyte membrane and its inhibition

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
We have studied the CO2 permeability of the erythrocyte membrane of the rat using a mass spectrometric method that employs 18 O-labelled CO2. The method yields, in addition, the intraerythrocytic carbonic anhydrase activity and the membrane HCO3 ...
Samer Al-Samir, Maximilian Prill, Claudiu T. Supuran, Gerolf Gros, Volker Endeward   +4 more
doaj   +1 more source

Alpha-toxin induces programmed cell death of human T cells, B cells, and monocytes during USA300 infection. [PDF]

PLoS ONE, 2012
This investigation examines the influence of alpha-toxin (Hla) during USA300 infection of human leukocytes. Survival of an USA300 isogenic deletion mutant of hla (USA300Δhla) in human blood was comparable to the parental wild-type strain and ...
Tyler K Nygaard, Kyler B Pallister, Ashley L DuMont, Mark DeWald, Robert L Watkins, Erik Q Pallister, Cheryl Malone, Shannon Griffith, Alexander R Horswill, Victor J Torres, Jovanka M Voyich   +10 more
doaj   +1 more source

Fabrication and Characterization of Chitosan/N-Phthaloyl Composite Membrane for DMFC Application

Jurnal Riset Kimia, 2021
Modified chitosan membrane is one of the promising membranes for polymer electrolyte membrane. Chitosan/N-phthaloyl chitosan composite membranes were fabricated to obtain high proton conductivity and low methanol permeability.
Christine Dyta Nugraeni, Lukman Atmaja, Nur Hayati, Mochammad Purwanto, Mardi Santoso, Yuli Kusumawati   +5 more
doaj   +1 more source

Systematic comparison of unilamellar vesicles reveals that archaeal core lipid membranes are more permeable than bacterial membranes.

PLoS Biology, 2023
One of the deepest branches in the tree of life separates the Archaea from the Bacteria. These prokaryotic groups have distinct cellular systems including fundamentally different phospholipid membrane bilayers.
Urszula Łapińska, Georgina Glover, Zehra Kahveci, Nicholas A T Irwin, David S Milner, Maxime Tourte, Sonja-Verena Albers, Alyson E Santoro, Thomas A Richards, Stefano Pagliara   +9 more
doaj   +1 more source

Genetic and Chemical-Genetic Interactions Map Biogenesis and Permeability Determinants of the Outer Membrane of Escherichia coli

mBio, 2020
Gram-negative bacteria are intrinsically resistant to many antibiotics due to their outer membrane barrier. Although the outer membrane has been studied for decades, there is much to uncover about the biology and permeability of this complex structure ...
Kristina Klobucar, Shawn French, Jean-Philippe Côté, James R. Howes, Eric D. Brown   +4 more
doaj   +1 more source