Results 41 to 50 of about 1,747,226 (292)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Permeability and topography of membranes
Chemistry and Physics of Lipids, 1972 In this brief review, we will report that the permeability of both artificial and natural membranes depends at least on the following lipid parameters: (1) The nature of the hydrocarbon chains of phospholipids. Because of a less compact packing of unsaturated phospholipids when compared with saturated ones, the former barrier will be more permeable ...
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Effect of Heat Treatment in Air on Hydrogen Permeation Through Pd Membrane
He huaxue yu fangshe huaxueIn order to study the effect of heat treatment in air on the hydrogen permeation in/through Pd membrane, Pd membrane was deposited via the electroless plating method and the hydrogen permeation flux of Pd membrane before and after heat treatment in air ...
YIN Zhao-hui +5 more
doaj +1 more source
Mechanistic Insights into Passive Membrane Permeability of Drug-Like Molecules from a Weighted Ensemble of Trajectories [PDF]
, 2021 Passive permeability of a drug-like molecule is a critical assay early in a drug discovery campaign that informs a medicinal chemist how well a compound can traverse biological membranes, such as gastrointestinal epithelial or restrictive organ barriers,
Forrest, York +7 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Growth and membrane permeability of two submersed macrophytes in response to ammonium enrichment
Aquatic Biology, 2013 Increased ammonium (NH4+) concentrations are reported to be an important cause of decline in submersed macrophytes in eutrophic lakes. In this study, a subacute experiment was conducted to examine the effects of various NH4+ concentrations on growth and ...
A Zhong, T Cao, L Ni, P Xie
doaj +1 more source
Data in Brief, 2021 Data of the osmotic water permeability of a lipid bilayer (diphytanoylphosphaticylcholin) in the presence of cholesterol (30 mole%) are shown under the simultaneous measurement of bilayer tension.
Keita Yano +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecules, 2015 In the present investigation we studied the molecular mechanisms of the monodesmosidic saponin digitonin on natural and artificial membranes. We measured the hemolytic activity of digitonin on red blood cells (RBCs). Also different lipid membrane models (
Ikhwan Resmala Sudji +4 more
doaj +1 more source