Results 51 to 60 of about 1,747,226 (292)

Alcohol Diffusion in Alkali-Metal-Doped Polymeric Membranes for Using in Alkaline Direct Alcohol Fuel Cells

Membranes, 2022
The alcohol permeability of anion exchange membranes is a crucial property when they are used as a solid electrolyte in alkaline direct alcohol fuel cells and electrolyzers.
Andrea Fernández-Nieto, Sagrario Muñoz, Vicenta María Barragán   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Neuronal Plasma Membrane Integrity is Transiently Disturbed by Traumatic Loading

Neuroscience Insights, 2020
The acute response of neurons subjected to traumatic loading involves plasma membrane disruption, yet the mechanical tolerance for membrane compromise, time course, and mechanisms for resealing are not well understood.
Gustavo R Prado, Michelle C LaPlaca
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Direct observation of defects and increased ion permeability of a membrane induced by structurally disordered Cu/Zn-superoxide dismutase aggregates. [PDF]

PLoS ONE, 2011
Interactions between protein aggregates and a cellular membrane have been strongly implicated in many protein conformational diseases. However, such interactions for the case of Cu/Zn superoxide dismutase (SOD1) protein, which is related to fatal ...
Inhee Choi, Hyeon Don Song, Suseung Lee, Young In Yang, Joo Hyun Nam, Sung Joon Kim, Jung-Joon Sung, Taewook Kang, Jongheop Yi   +8 more
doaj   +1 more source

Carbon nanotube based composite membranes for water desalination by membrane distillation [PDF]

, 2010
New technologies are required to improve desalination efficiency and increase water treatment capacities. One promising low energy technique to produce potable water from either sea or sewage water is membrane distillation (MD).
Ludovic Dumée, Sears, Kallista, Stephen Gray, Finn, Niall, Kallista Sears, Niall Finn, Gray, Stephen, Duke, Mikel, Jü rg Schü tz, Dumee, Ludovic, Gray, Stephen R, Mikel Duke   +11 more
core   +1 more source

SVM and ANN Modelling Approach for the Optimization of Membrane Permeability of a Membrane Rotating Biological Contactor for Wastewater Treatment

, 2022
Membrane fouling significantly hinders the widespread application of membrane technology. In the current study, a support vector machine (SVM) and artificial neural networks (ANN) modelling approach was adopted to optimize the membrane permeability in a ...
Arshad, Ushtar, Waqas, Sharjeel, Nordin, Nik Abdul Hadi Md, Sambudi, Nonni Soraya, Nik Abdul Hadi Md Nordin, Asher Ahmed Malik, Ushtar Arshad, Muhammad Roil Bilad, Noorfidza Yub Harun, Bilad, Muhammad Roil, Malik, Asher Ahmed, Saeed, Anwar Ameen Hezam, Harun, Noorfidza Yub, Sharjeel Waqas, Nonni Soraya Sambudi, Anwar Ameen Hezam Saeed   +15 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Liposome-integrated seawater reverse osmosis membrane prepared via facile spray-assisted interfacial polymerization

, 2022
In this work, we demonstrated the effectiveness of using spray-assisted interfacial polymerization (IP) technique in fabricating liposome-integrated thin film nanocomposite (TFN) membranes for seawater reverse osmosis (SWRO).
Zhao, Yali, Wang, Rong, Lai, Gwo Sung
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source