Results 91 to 100 of about 628,659 (381)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

MultiCycPermea: accurate and interpretable prediction of cyclic peptide permeability using a multimodal image-sequence model

BMC Biology
Background Cyclic peptides, known for their high binding affinity and low toxicity, show potential as innovative drugs for targeting “undruggable” proteins. However, their therapeutic efficacy is often hindered by poor membrane permeability.
Zixu Wang, Yangyang Chen, Yifan Shang, Xiulong Yang, Wenqiong Pan, Xiucai Ye, Tetsuya Sakurai, Xiangxiang Zeng   +7 more
doaj   +1 more source

CORRELATION BETWEEN POLYMER PACKING AND GAS TRANSPORT PROPERTIES FOR CO2/N2 SEPARATION IN GLASSY FLUORINATED POLYIMIDE MEMBRANE [PDF]

Journal of Engineering Science and Technology, 2016
Gas separation performance of a membrane highly hinges on its physical properties. In this study, the interplay between polymer packing of a membrane and its gas transport behaviours (permeability and selectivity) was investigated through a series of ...
P. C. TAN, Z. A. JAWAD, B. S. OOI, A. L. AHMAD, S. C. LOW   +4 more
doaj  

CO2 Permeability of Biological Membranes and Role of CO2 Channels

Membranes, 2017
We summarize here, mainly for mammalian systems, the present knowledge of (a) the membrane CO2 permeabilities in various tissues; (b) the physiological significance of the value of the CO2 permeability; (c) the mechanisms by which membrane CO2 ...
Volker Endeward, Mariela Arias-Hidalgo, Samer Al-Samir, Gerolf Gros   +3 more
doaj   +1 more source

Combined Effect of Nitrofurantoin and Plant Surfactant on Bacteria Phospholipid Membrane

Molecules, 2020
Due to the increasing use of antibiotics, measures are being taken to improve their removal from the natural environment. The support of biodegradation with natural surfactants that increase the bioavailability of impurities for microorganisms that ...
Monika Rojewska, Wojciech Smułek, Krystyna Prochaska, Ewa Kaczorek   +3 more
doaj   +1 more source

Mass transfer, fluid flow and membrane properties in flat and corrugated plate hyperfiltration modules [PDF]

, 1986
Concentration polarisation, decreasing the efficiency in membrane separation processes, can be reduced by increasing mass transfer between membrane surface and bulk of the feed stream.
Groot Wassink, J., Klaassen, R., Rácz, I.G.   +2 more
core   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Lysosome membrane permeability to amines

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1997
The permeability of rat liver lysosomes to xenobiotic organic compounds possessing nitrogen functions was investigated, using an osmotic-protection methodology. It was first shown that rat liver lysosomes are stable for at least one hour when incubated in 250 mM sucrose within the pH range 5 to 9. Primary and tertiary amines with pKa values within this
Andrew, Carole L, Klemm, Ann R, Lloyd, John B   +2 more
openaire   +2 more sources

The stability of supported liquid membranes [PDF]

, 1990
In this paper a new hypothesis about the instability mechanism of SLMs will be discussed: emulsion formation induced by lateral shear forces. Experimental results show that a water phase with a low salt concentration which flows along the membrane ...
Bargeman, D., Bargeman, D., Neplenbroek, A.M., Neplenbroek, A.M., Smolders, C.A., Smolders, C.A.   +5 more
core   +3 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source