Results 81 to 90 of about 628,659 (381)

Molecular Dynamics Simulations of Water Anchored in Multi-Layered Nanoporous MoS$_2$ Membranes: Implications for Desalination [PDF]

arXiv, 2021
One of the most promising applications in nanoscience is the design of new materials to improve water permeability and selectivity of nanoporous membranes. Understanding the molecular architecture behind these fascinating structures and how it impacts the water flow is an intricate but necessary task.
arxiv  

Electrochemically Modulated Permeability of Poly(aniline) and Composite Poly(aniline)−Poly(styrenesulfonate) Membranes [PDF]

, 2006
The influence of oxidation state on the permeability of several probe molecules through conducting polymer membranes comprising composites of poly(aniline) and poly(styrenesulfonate) was examined in aqueous solution.
Hillier, Andrew, Hillier, Andrew, Pile, D., Zhang, Y.   +3 more
core   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Calculation of Permeability Coefficients from Solute Equilibration Dynamics: An Assessment of Various Methods

Membranes, 2022
Predicting the rate at which substances permeate membrane barriers in vivo is crucial for drug development. Permeability coefficients obtained from in vitro studies are valuable for this goal.
Margarida M. Cordeiro, Armindo Salvador, Maria João Moreno   +2 more
doaj   +1 more source

Frozen states and order-disorder transition in the dynamics of confined membranes [PDF]

Phys. Rev. E 90, 032114 (2014), 2014
The adhesion dynamics of a membrane confined between two permeable walls is studied using a two-dimensional hydrodynamic model. The membrane morphology decomposes into adhesion patches on the upper and the lower walls and obeys a nonlinear evolution equation that resembles that of phase separation dynamics, which is known to lead to coarsening, i.e. to
arxiv   +1 more source

Investigating membrane breakdown of neuronal cells exposed to nonuniform electric fields by finite-element modeling and experiments [PDF]

, 2002
High electric field strengths may induce high cell membrane potentials. At a certain breakdown level the membrane potential becomes constant due to the transition from an insulating state into a high conductivity and high permeability state.
Heida, Tjitske, Marani, Enrico, Rutten, Wim L.C., Wagenaar, Joost B.M.   +3 more
core   +3 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Numerical method to characterise capsule membrane permeability for controlled drug delivery [PDF]

arXiv, 2021
Design and characterisation of capsules is not an easy task owing to the multiple involved preparation factors and parameters. Here, a novel method to characterise capsule membrane permeability to solute molecules by an inverse approach is proposed. Transport of chemical species between the capsule core and the surrounding medium through the membrane ...
arxiv  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Optimization of experimental conditions for skin-PAMPA measurements

ADMET and DMPK, 2020
In recent years, the parallel artificial membrane permeability assay (PAMPA) has been extended for prediction of skin permeation by developing an artificial membrane which mimics the stratum corneum structure, skin-PAMPA.
Sara Soriano-Meseguer, Elisabet Fuguet, Adriana Port, Martí Rosés   +3 more
doaj   +1 more source