Results 31 to 40 of about 474,230 (265)
Journal of Ovarian Research, 2021 Mitochondrial injury in granulosa cells (GCs) is associated with the pathophysiological mechanism of polycystic ovary syndrome (PCOS). Melatonin reduces the mitochondrial injury by enhancing SIRT1 (NAD-dependent deacetylase sirtuin-1), while the ...
Bo Zheng +5 more
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Modulation of myometrium mitochondrial membrane potential by calmodulin antagonists [PDF]
The Ukrainian Biochemical Journal, 2014 Influence of calmodulin antagonists on mitochondrial membrane potential was investigated using a flow cytometry method, confocal microscopy and fluorescent potential-sensitive probes TMRM and MTG.
S. G. Shlykov +4 more
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Mitochondrial membrane potential and aging
Aging Cell, 2003 SummaryThe mitochondrial membrane potential (or protonmotive force) is the central bioenergetic parameter that controls respiratory rate, ATP synthesis and the generation of reactive oxygen species, and is itself controlled by electron transport and proton leaks.
openaire +2 more sources
Platelet mitochondrial membrane potential in Parkinson's disease [PDF]
Annals of Clinical and Translational Neurology, 2014 AbstractObjectiveMitochondrial dysfunction is a hallmark of idiopathic Parkinson's disease (IPD), which has been reported not to be restricted to striatal neurons. However, studies that analyzed mitochondrial function at the level of selected enzymatic activities in peripheral tissues have produced conflicting data. We considered the electron transport
Paul M. A. Antony +10 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Neurobiology of Disease, 2011 Mutations in PTEN-induced putative kinase 1 (PINK1) cause a recessive form of Parkinson's disease (PD). PINK1 is associated with mitochondrial quality control and its partial knock-down induces mitochondrial dysfunction including decreased membrane ...
Taku Amo +8 more
doaj +1 more source
Antioxidants, 2022 Recent studies have related mitochondrial impairment with peritoneal membrane damage during peritoneal dialysis (PD) therapy. Here, we assessed the involvement of mitochondrial dysfunction in the inflammatory response in human mesothelial cells, a ...
Olalla Ramil-Gómez +7 more
doaj +1 more source
Imaging mitochondrial membrane potentials
Biophysical Journal, 1993 process remain to be elucidated. The elusiveness of this goal can be attributed, at least in part, to the absence of structural information about the mitochondrion itself at several levels of complexity. It is obvious, for example, that obtaining atomic structures of the respiratory chain protein complexes by x-ray or electron crystallography would ...
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Bio-Protocol, 2019 In recent years, fluorescent dyes have been frequently used for monitoring mitochondrial membrane potential to evaluate mitochondrial viability and function.
Farzane Sivandzade +2 more
doaj +1 more source