Results 131 to 140 of about 14,693,728 (394)

Stochastic Dynamics of Electrical Membrane with Voltage-Dependent Ion Channel Fluctuations

, 2014
Brownian ratchet like stochastic theory for the electrochemical membrane system of Hodgkin-Huxley (HH) is developed. The system is characterized by a continuous variable $Q_m(t)$, representing mobile membrane charge density, and a discrete variable $K_t$
Qian, Hong, Qian, Min, Zhang, Xue-Juan
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels

Respiratory Research, 2000
Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in
Yuan Jason, Sweeney Michèle
doaj   +1 more source

Analyzing the effects of surface distribution of pores in cell electroporation for a cell membrane containing cholesterol

, 2008
This paper presents a model and numerical analysis (simulations) of transmembrane potential induced in biological cell membrane under the influence of externally applied electric field (i.e., electroporation).
DeBruin K A, DeBruin K A, Hibino M, Jamieson G, Karatekin E, Krassowska W, Pandit B Vidyasagar, Pratip Shil, Salil Bidaye, Shil P, Shil P, Smith K C   +11 more
core   +1 more source

Cellular Membrane Potentials and Contractility of Normal Rat Atrium and the Effects of Temperature, Tension and Stimulus Frequency [PDF]

, 1955
Philip B. Hollander, J. Webb
openalex   +1 more source

Alteration of Zeta potential and membrane permeability in bacteria: a study with cationic agents

SpringerPlus, 2015
In the present study, we have tried to establish the correlation between changes in Zeta potential with that of cell surface permeability using bacteria (Escherichia coli and Staphylococcus aureus).
S. Halder, K. K. Yadav, Ratul Sarkar, S. Mukherjee, P. Saha, S. Haldar, Sanmoy Karmakar, T. Sen   +7 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Optical estimation of absolute membrane potential using fluorescence lifetime imaging

eLife, 2019
All cells maintain ionic gradients across their plasma membranes, producing transmembrane potentials (Vmem). Mounting evidence suggests a relationship between resting Vmem and the physiology of non-excitable cells with implications in diverse areas ...
Julia R Lazzari-Dean, Anneliese MM Gest, Evan W Miller   +2 more
doaj   +1 more source

Targeting Membrane Lipid a Potential Cancer Cure?

Frontiers in Pharmacology, 2017
Cancer mortality and morbidity is projected to increase significantly over the next few decades. Current chemotherapeutic strategies have significant limitations, and there is great interest in seeking novel therapies which are capable of specifically ...
Loh Teng-Hern Tan, Kok-Gan Chan, Priyia Pusparajah, Wai-Leng Lee, L. Chuah, T. Khan, Learn‐Han Lee, B. Goh   +7 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source