Results 21 to 30 of about 10,023,283 (299)

A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma.

PLoS Computational Biology, 2021
Lung cancer is still a leading cause of death worldwide. In recent years, knowledge has been obtained of the mechanisms modulating ion channel kinetics and thus of cell bioelectric properties, which is promising for oncological biomarkers and targets ...
Sonja Langthaler, Theresa Rienmüller, Susanne Scheruebel, Brigitte Pelzmann, Niroj Shrestha, Klaus Zorn-Pauly, Wolfgang Schreibmayer, Andrew Koff, Christian Baumgartner   +8 more
doaj   +1 more source

Periodic Membrane Potential and Ca2+ Oscillations in T Cells Forming an Immune Synapse

International Journal of Molecular Sciences, 2020
The immunological synapse (IS) is a specialized contact area formed between a T cell and an antigen presenting cell (APC). Besides molecules directly involved in antigen recognition such as the TCR/CD3 complex, ion channels important in the membrane ...
F. Papp, P. Hajdú, G. Tajti, Á. Tóth, Éva Nagy, Z. Fazekas, Sándor Kovács, G. Vámosi, Z. Varga, G. Panyi   +9 more
semanticscholar   +1 more source

Neural coding with graded membrane potential changes and spikes [PDF]

, 2001
Kretzberg J, Warzecha A-K, Egelhaaf M. Neural coding with graded membrane potential changes and spikes. Journal of computational neuroscience. 2001;11(2):153-164.The neural encoding of sensory stimuli is usually investigated for spike responses, although
Egelhaaf, Martin ; https://orcid.org/, Warzecha, Anne-Kathrin, Kretzberg, Jutta   +2 more
core   +1 more source

The pros and cons of degeneracy

eLife, 2014
Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.
Jean-Marc Goaillard, Martial A Dufour
doaj   +1 more source

Branching dendrites with resonant membrane: a “sum-over-trips” approach [PDF]

, 2007
Dendrites form the major components of neurons. They are complex branching structures that receive and process thousands of synaptic inputs from other neurons.
Cox, Steven J., Lord, G. J., Lord, Gabriel, Timofeeva, Yulia, Svensson, C. M., Lord, G. J. (Gabriel J.), Timofeeva, Y., Coombes, Stephen, Svensson, Carl-Magnus, Cox, S. J., Colbert, Costa M., Coombes, S., Josić, K., C.-M. Svensson, Colbert, C. M., K. Josić, Josić, Krešimir, Y. Timofeeva, S. Coombes, Svennson, Carl-Magnus, G. J. Lord, C. M. Colbert, Colbert, Costa, S. J. Cox   +23 more
core   +1 more source

Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

eLife, 2014
Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability.
Stéphanie Ratté, Yi Zhu, Kwan Yeop Lee, Steven A Prescott   +3 more
doaj   +1 more source

The relationship between respiration-related membrane potential slow oscillations and discharge patterns in mitral/tufted cells: what are the rules? [PDF]

PLoS ONE, 2012
A slow respiration-related rhythm strongly shapes the activity of the olfactory bulb. This rhythm appears as a slow oscillation that is detectable in the membrane potential, the respiration-related spike discharge of the mitral/tufted cells and the ...
Virginie Briffaud, Nicolas Fourcaud-Trocmé, Belkacem Messaoudi, Nathalie Buonviso, Corine Amat   +4 more
doaj   +1 more source

How DASPMI reveals mitochondrial membrane potential : fluorescence decay kinetics and steady-state anisotropy in living cells [PDF]

, 2008
Spectroscopic responses of the potentiometric probe 2-(4-(dimethylamino)styryl)-1-methylpyridinium iodide (DASPMI) were investigated in living cells by means of a time- and space-correlated single photon counting technique.
Ramadass, Radhan, Bereiter-Hahn, Jürgen
core   +1 more source

Regulation of [Ca2+]i oscillations and mitochondrial activity by various calcium transporters in mouse oocytes

Reproductive Biology and Endocrinology, 2020
Oocyte activation inefficiency is one of the reasons for female infertility and Ca2+ functions play a critical role in the regulation of oocyte activation.
Feng Wang, Ang Li, Tie-Gang Meng, Le-Yun Wang, Li-Juan Wang, Yi Hou, Heide Schatten, Qing-Yuan Sun, Xiang-Hong Ou   +8 more
doaj   +1 more source

The styrene-maleic acid copolymer:: a versatile tool in membrane research [PDF]

, 2016
A new and promising tool in membrane research is the detergent-free solubilization of membrane proteins by styrene-maleic acid copolymers (SMAs). These amphipathic molecules are able to solubilize lipid bilayers in the form of nanodiscs that are bounded ...
Sub Membrane Biochemistry & Biophysics, Scheidelaar, Stefan, Dominguez Pardo, Juan, Killian, J Antoinette, Membrane Biochemistry and Biophysics, Dörr, Jonas M, Schäfer, Marre, Koorengevel, Martijn C, van Walree, Cornelis A   +8 more
core   +2 more sources