Results 91 to 100 of about 9,542,103 (311)

Photothermal-enhanced and fouling-resistant membrane for solar-assisted membrane distillation

, 2018
Membrane distillation (MD) has been gaining increasing attention as a promising alternative to the more conventional separation processes like distillation and reverse osmosis (RO), due to the higher rejection, lower fouling propensity and ability to ...
Tanis-Kanbur, Melike Begum, Wang, Hou, Pranav, Mehta Vidish, Tan, Yong Zen, Han, Le, Chew, Jia Wei   +5 more
core   +1 more source

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug‐Resistant Acinetobacter baumannii Growth and Biofilm Formation While Demonstrating Safety in Pre‐Clinical Pilot Human Trials

Advanced Healthcare Materials, EarlyView.
Using PVA–borax hydrogels as carriers for off‐the‐shelf artificial sweeteners to fight multidrug‐resistant A. baumannii. These soft, biocompatible hydrogels rapidly reduce bacterial viability within multidrug‐resistant A. baumannii biofilms by more than 99% within one hour and sustain antimicrobial activity over time, while demonstrating safety in both
Jie Han, Mohamed Soliman, Bin Zhang, Dominika Krawiel, Ronan R. McCarthy   +4 more
wiley   +1 more source

Understanding membrane pore-wetting in the membrane distillation of oil emulsions via molecular dynamics simulations

, 2018
The escalating volume of oily wastewater, particularly produced water, necessitates efficient means of treatment for the recovery of both the water and oil constituents. Towards this end, membrane distillation (MD) is a promising candidate. Unfortunately,
Le Han, Velioğlu, Sadiye, Sadiye Velioğlu, Han, Le, Jia Wei Chew, Chew, Jia Wei   +5 more
core   +1 more source

Factors influencing the solubilization of membrane proteins from Escherichia coli membranes by styrene–maleic acid copolymers [PDF]

, 2020
Styrene–maleic acid (SMA) copolymers are a promising alternative to detergents for the solubilization of membrane proteins. Here we employ Escherichia coli membranes containing KcsA as a model protein to investigate the influence of different ...
Dörr, Jonas M., Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics, Koorengevel, Martijn C., Jahn, Helene, Killian, J. Antoinette, Antoniciello, Federico, Kopf, Adrian H.   +7 more
core   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities. [PDF]

, 2011
Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored.
Wei-Lien Tseng, Yu-Sun Chang, Tsung-Yu Chen, Tien-Shen Lew, Szecheng J. Lo, Yung-Hsiang Yi, Chi-Hung Lin, Ching-Ping Tseng, Chih-Yung Tang   +8 more
core  

Effect of membrane fouling on chiral separation

, 2020
Chiral purity is becoming increasingly critical particularly for the pharmaceutical industry. Compared to the conventional techniques, membrane-based separation is promising as an easily scalable, efficient, continuous operation. Past studies have proven
Meilan Pan, Tian, Ju, Ju Tian, Ma, Yunqiao, Yunqiao Ma, Pan, Meilan, Jia Wei Chew, Chew, Jia Wei   +7 more
core   +1 more source

The mass-hierarchy and CP-violation discovery reach of the LBNO long-baseline neutrino experiment [PDF]

, 2013
The next generation neutrino observatory proposed by the LBNO collaboration will address fundamental questions in particle and astroparticle physics.
Gavrilov, G., A. Ereditato, G. Gavrilov, Tsenov R, J. Sarkamo, Novikov, Y.u., R. Terri, Gorodetzky, P, Agarwalla, SK, W. Bartmann, Gendotti, A, Spooner N, Kryn, D, Magaletti L, Thompson, LF, Giganti C, Sarkamo, J., Crivelli, Paolo, M. Weber, Morgan, B. (Ben), Berardi, V., Ilic J, Loo K, V. Palladino, Sergiampietri, F., Saviano, N., A.M. Blebea-Apostu, Wilson, J.R., Ravonel M, J. Coleman, Cantini, C., Catanesi, M.G., Sanchez, P. D. A., Kudryavtsev, V. A., De Bonis, I, Autiero D, Radicioni, E., I. Bandac, B. Still, Kormos LL, K. Huitu, Sato F, Sgalaberna, D, Radicioni E, Angus, D., Thompson, L. F., I. Bertram, Ereditato, A, J.-M. Levy, Rummukainen K, Agarwalla, Sanjib Kumar, M.G. Catanesi, Quinto, M, Litchfield R, C. Cantini, Horikawa, Sosuke, Resnati F, Sakashita K, S. Emery, A. Gendotti, Pascoli, S, Noah E, P. Ballett, Brancus, I., F. Cafagna, Ioannisian, AN, Kalliokoski, T., Sakashita, K, Hissa, J, Buizza-Avanzini, M., Wilson JR, Eliseev, A., Agarwalla, S.K., Boyd S, Y. Karadzhov, H. Vincke, Spooner, N.j.c., Velten, P., Vacheret A, Bartmann W, Crivelli, P., Cervera Villanueva, Anselmo, A.J. Finch, Palladino, V., C. Densham, Barr, G., Tonazzo A, Ariga, T, Wiebusch, C., et al., Matveev, V., Kopylov, A.N., F. Velotti, Gomez, J. J., T. Esanu, Bogomilov, M, Slupecki, M, Cata-Danil, G., L.L. Kormos, Mavrokoridis K, Grant, Nick, I. Efthymiopoulos, Palladino, V, Di Luise S, Murphy S, M. Murdoch, M. Valram, M. Zito, Mercadante, A., Payne D, O. Caretta, E. Radicioni, K. Tuominen, Chesneanu, D., I. Kreslo, N.J.C. Spooner, Sgalaberna, Davide, Dumarchez, J., Pistillo, C, Loo, K., Horikawa, S, Kokko, E, Hierholzer, M, P. Velten, Christodoulou G, V. Matveev, Scantamburlo, E, Martin Mari, C., Mercadante A, Cervera, A., Asfandiyarov R, Haesler, A, Kokko, E., Still B, Eliseev A, Banerjee, Daipayan, Matveev V, Nesterenko D, Barr, G, Ariga, A, Rummukainen, K., Vasseur, G, Kainulainen K, Loo, K, Coleman, J., Korzenev, A, F. Resnati, Buizza-Avanzini, M, Stahl, Achim, Wu, S, D. Kryn, S.K. Agarwalla, Saftoiu, A, Ratoff P, Mirizzi A, Catanesi, M. G., Strauss, T., Bogomilov, M., Viant, T, G. Christodoulou, K. Mursula, Novikov, Yu., Luise, SD, Catanesi M, Touramanis C, De Jong J, A. Tonazzo, Litchfield, R. P., M. Hierholzer, R.P. Litchfield, J. Zalipska, Haesler, A., Pistillo C, H. O’Keeffe, Erykalov AN, Kormos, Laura, Wiebusch C, M. Rayner, Margineanu R, Trzaska W, M. Buizza-Avanzini, Hasegawa T, Blebea-Apostu AM, Pectu M, Enqvist, T, Galymov, V., N. McCauley, Sakashita, K., Kudryavtsev, VA, A.N. Kopylov, Del Amo Sanchez, P., Boyd, S, S. Pascoli, Zito, M, Terri, R., Magaletti, L., Kumpulainen, J, Oprima, A, Periale, L, Pessard H, Cantini, Cosimo, Valram M, Terri, R, J. Dumarchez, Popov, B, Enqvist, K, Mitrica, B., Kopylov, A. N., Di Lodovico F, Vanucci, F, Stoica, S, D. Autiero, Kuusiniemi P, Tuominen, K, Fitton M, W.H. Trzaska, P. Crivelli, T. Enqvist, Szeptycka, M., Finch A, Gomoiu, C. M., Epprecht, L, Agarwalla S, O'Keeffe H, Przewlocki P, Trzaska, WH, Trzaska, W.H., L. Agostino, Angus, D, Bertram, I, Y. Papaphilippou, Toma, G., A.N. Ioannisian, Duchesneau D, Odell, J., S. Horikawa, Kreslo, I, Lazanu, I, Pessard, H, Jipa, A., Esanu, T, Esanu, T., Campanelli, M, Virtanen, A, MAGALETTI, Lorenzo, Buizza-Avanzini M, Odell, J, Kalliokoski, T, Calviani M, Mineev, O., Valram, M, O. Bésida, Rayner, M., Haigh, M. D., Andrieu, B, Catanesi MG, Asfandiyarov, R., Franco, D., Stanca, D, Barker, GJ, Gornushkin, Y.A., Korzenev, A., Bonis, ID, G. J. Barker, Zalipska J, Calin, M, Sacco, R., E. Borriello, D. Stanca, Kawada, J, Lazanu I, Wiebusch, Christopher, T. Ariga, Bertram I, Brancus, I, Gomoiu C, C. Pistillo, Dawson, J, Bay F, Vankova-Kirilova, G., Velten, P, Berardi, V, Y. Kudenko, A. Mercadante, Murphy, S, M. Aittola, Gomoiu CM, Autiero, D, Virtanen, A., Litchfield, R.P., Di Lodovico, F, Campanelli M, Rubbia, A., Periale, Luciano, Cervera A, Mineev, O, Caretta O, T. Hasegawa, M. Quinto, Litchfield, Reuban P., Sorel, Michel, Periale, L., Maalampi J, Murdoch, M, Litchfield, RP, A. Delbart, Trzaska WH, G. Barr, De Bonis, I., Dawson J, Chesneanu, D, Zalipska, J., Levy JM, A. Vacheret, Haug S, Oprima, A., Blebea-Apostu A, Hierholzer, M., Bogomilov M, Cafagna F, F. Sato, Declais, Y, C.M. Gomoiu, Kreslo I, B. Morgan, Matveev, V, J. Dawson, Loveridge P, Chesneanu D, Hierholzer M, M.D. Haigh, Gavrilov, G, Still, B., Yu. Novikov, Morgan, B., Velotti, F, De Bonis I, Horikawa S, Gorodetzky P, Pennacchio, E., Rayner, M, A. Alekou, Przewlocki, P, A. Virtanen, De Jong, J, Galymov, V, Kawada J, Gomez J, Franco D, Rondio, E., Thompson L, Déclais, Y., Haigh M, Margineanu, R.M., L. Chaussard, Suhonen, J., Cantini, C, Wilson J, P. Del Amo Sanchez, J. Odell, Weber, A., Bandac I, M.D. Fitton, L. Epprecht, J. Suhonen, Hissa J, Kudenko Y, Blebea-Apostu, A. M., Kudryavtsev V, Ristea, O, G. Vasseur, Efthymiopoulos, I., P. Przewlocki, Nikolics, K, Brancus I, Huitu K, Mitrica B, A. Oprima, Thompson LF, Rubbia, André, Shaposhnikova, E., Gornushkin, Y. A., P. Loveridge, Levy, J. M., Korzenev A, Coleman, J, Gomoiu, CM, F. Antoniou, J. Marteau, Valram, M., E. Kokko, Banerjee, D, Haigh, MD, Tuominen K, Duchesneau, D., Catanesi, MG, L. Periale, Gendotti, Adamo, V.A. Kudryavtsev, Campanelli, M., E. Rondio, Haigh MD, M. Calin, Sarkamo, J, Nikolics K, Suhonen, J, Murdoch M, Antoniou, F., Vankova-Kirilova, G, Litchfield RP, Chaussard L, Franco, D, Bertram, I., Levy, J. -M., Duchesneau, D, B. Goddard, Buizza Avanzini, M., Ramachers Y, O’keeffe, H., Kuusiniemi, P., N. Saviano, G. Cata-Danil, Papaphilippou, Y, Huitu, K., Chipesiu, F, A. Eliseev, Ballett, P., M. Campanelli, Noah, E, J.R. Wilson, D. Sgalaberna, Berardi V, A.N. Erykalov, Blondel, A, Cafagna, F, Bandac, I., Wilson, JR, Ratoff, PN, Szeptycka, M, J.J. Gomez, Karadzhov, Y., Steerenberg, R, Emery, S, Vorobyev, A., Rubbia A, Chakraborty, S., Grant, N., Galymov V, I. Lazanu, Khotjantsev, A, Khabibullin, M, A. Vorobyev, Sergiampietri F, Ratoff, P.N., Borriello E, Sgalaberna D, Christodoulou, G, Virtanen A, Resnati, F, K. Sakashita, O'Keeffe, H., Morgan, B, Finch, Alex, Aittola, M, Morgan B, L. Magaletti, R.M. Margineanu, Chaussard, L, E. Scantamburlo, Rummukainen, K, Fitton, M. D., Dumarchez J, Antoniou, F, Lagoda J, Wark D, Kudenko, Y., Sgalaberna, D., Fitton MD, A. Weber, Kopylov, AN, Tuominen, K., Rubbia, A, Haesler A, Levy, J.-M., Robert, A., Levy, JM, Chaussard, L., Zito M, Lagoda, J., B. Andrieu, Efthymiopoulos I, Levy J, Sterian, P., Stahl A, Karadzhov, Y, Gendotti, A., Rondio E, Margineanu, R. M., Densham C, Gomez JJ, Goddard, B, Borriello, E, Kopylov A, Loveridge, P., Horikawa, S., Densham, C, Epprecht, L., Fitton, M.D., Murphy, S., Cervera, A, Mirizzi, A., Tonazzo, A., Wu, S., Kumpulainen, J., O. Mineev, Haigh, Martin David, M. Bogomilov, K. Loo, K. Mavrokoridis, Agarwalla, S.K, HASH(0x55a67fd79a80), Kormos, L. L., S. Murphy, D. Banerjee, Enqvist K, Toma G, R. Asfandiyarov, Nikolics, K., Enqvist T, J. Hissa, Kudenko, Y, M. Szeptycka, T. Patzak, Caretta, O, Izmaylov A, E. Noah, Kalliokoski T, S. Chakraborty, V. Galymov, Touramanis, C., Goddard B, Calviani, M, Steerenberg, R., V. Berardi, D. Chesneanu, Mitrica, B, M. Slupecki, E. Pennacchio, Khotjantsev, A., Saviano, N, D.A. Nesterenko, Delbart, A., S. Narita, A. Bravar, Scantamburlo, E., Eliseev, A, I. Brancus, Marteau, J., Vacheret, A., Lazanu, I., Lagoda, J, Velotti, F., Viant, T., C. Wiebusch, Popov, B., Patzak T, Aittola M, Novikov, Y, T. Strauss, N. Grant, A. Ariga, Nesterenko, DA, Jong, JD, Martin-Mari C, Sterian, A.r., Kosyanenko, S, Kuusiniemi, P, F. Vanucci, Vanucci F, Pectu, M., E. Shaposhnikova, R. Steerenberg, Velten P, Suvorov, V, Gómez Cadenas, Juan José, Sergiampietri, F, Steerenberg R, Bravar A, Haug, S, Strauss T, Mazzucato, E, Tuominen, Kimmo Ilmari, Dumarchez, J, Agarwalla, S. K., Sanchez PD, Ballett P, Gendotti A, Delbart, A, R. Sacco, F. Di Lodovico, D. Wark, K. Kainulainen, Sacco, R, Mineev O, Gorodetzky, P., Bay, Francesca, Kainulainen, K, Barker, G. J., Boyd, S., K. Enqvist, Kudryavtsev VA, A. Jipa, Viant, Thierry, McCauley N, Patzak, T., PALLADINO, VITTORIO, Margineanu, RM, D. Angus, Kudryavtsev, V.a., Bay, F, J. Kawada, Quinto M, C. Giganti, Crivelli P, Vorobyev A, Emery, S., Mazzucato E, Thompson, L.F., Patzak, T, Sterian A, Zito, M., Kormos, L.L., Touramanis, C, Khabibullin M, Sarkamo J, Sterian P, O. Ristea, Kumpulainen J, Marteau, J, D. Payne, Davenne, T., Yershov, N, Vanucci, F., Vasseur G, Haug, S., Rondio, E, Still, B, Calin, M., Agostino, L., Barr G, Saftoiu, A., Kainulainen, K., G. Toma, Gornushkin Y, Yershov, N., Hissa, J., J. Maalampi, B. Mitrica, Nguyen, K., Ilic, J, Sorel, M, Alekou A, Karadzhov Y, Sato, F, Huitu, K, Barker GJ, Velotti F, Erykalov, A.N., Mavrokoridis, K., Blondel, A., Finch, AJ, Loveridge, P, Izmaylov, A, Pennacchio, E, E. Mazzucato, Bartmann, W, Novikov Y, Cafagna, F., Delbart A, Ariga, T., P. Sterian, Sterian, A. R., Sorel, M., Wilson, J. R., Hasegawa, T, Epprecht, Lukas, Spooner, NJC, Collaboration, LAGUNALBNO, Trzaska, W. H., Bandac, I, Weber, M., Goddard, B., Chakraborty S, Bésida, O, Ilic, J., Gornushkin, YA, O’Keeffe H, Kopylov AN, Grant N, Odell J, Murphy, Sébastien, Stoica, S., Antoniou F, Saviano N, Radicioni, E, A. Stahl, Haigh, M.D., Kosyanenko, S., Giganti, C., Del Amo Sanchez P, Erykalov, AN, J. Ilic, Pessard, H., Palladino V, Suvorov V, Nesterenko, D. A., N. Yershov, Collaboration, LAGUNA-LBNO, Wark, D, A.R. Sterian, S. Boyd, Magaletti, L, Margineanu RM, Narita, S., Densham, C., Kormos, LL, Nesterenko DA, Mursula K, F. Sergiampietri, Alekou, A, Chakraborty, S, Stahl, A, Vankova Kirilova, G., McCauley, N, Tonazzo, A, Ristea, O., J. De Jong, A. Cervera, Stoica S, Nguyen, K, S. Di Luise, Martin-Mari, C, Yershov N, Ioannisian, A. N., Scantamburlo E, C. Martin-Mari, Finch, A. J., Di Luise, S, T. Viant, G. Vankova-Kirilova, H. Pessard, Slupecki M, Bésida, O., Ariga T, Ramachers, Y., Davenne T, null null, Ereditato, A., Y.A. Gornushkin, Kawada, J., Popov B, Payne, D., M. Sorel, Stanca, D., Ariga A, B. Popov, Gomez, JJ, Terri R, Przewlocki, P., Sterian, P, Ravonel, M., Finch, A.J., M. Khabibullin, Blebea-Apostu, AM, Ravonel, M, Di Luise, Silvestro, Stanca D, Cata-Danil, G, Y. Déclais, Quinto, M., Spooner NJC, F. Chipesiu, Kryn D, Barker, G.J., K. Rummukainen, Kokko E, Enqvist, K., P. Kuusiniemi, Resnati, Filippo, Agarwalla SK, A. Rubbia, F. Bay, Christodoulou, G., Andrieu B, Di Luise, S., Aittola, M., O'Keeffe, H, Murdoch, M., A. Korzenev, Banerjee, D., Chipesiu F, S. Stoica, A. Saftoiu, Blondel A, Strauss, T, Slupecki, M., Deeclais Y, Toma, G, A. Khotjantsev, Bravar, A., Blebea Apostu, A. M., T. Davenne, Vincke, H, Cata Danil, G., Gomoiu, C.M., Ratoff, P. N., Fitton, MD, Mavrokoridis, K, LAGUNA-LBNO Collaboration, J. Lagoda, Spooner, N. J. C., J. Kumpulainen, Khabibullin, M., Mursula, K., Szeptycka M, Gornushkin YA, Autiero, D., Wiebusch, C, Borriello, E., Bertram, Iain, Payne, D, Epprecht L, Weber M, Lodovico, FD, Giganti, C, Agostino L, Caretta, O., Weber A, Tsenov, R, R. Tsenov, Vacheret, A, McCauley, N., Ereditato A, Efthymiopoulos, I, Maalampi, J., S. Kosyanenko, Emery S, Calviani, M., Izmaylov, A., C. Touramanis, Noah, E., Erykalov, A. N., I. De Bonis, Pennacchio E, Sorel M, Andrieu, B., Marteau J, Oprima A, Vankova-Kirilova G, Grant, N, Sacco R, Calin M, Rayner M, Coleman J, Suvorov, V., M. Ravonel, D. Duchesneau, Ramachers, Y, Di Lodovico, F., S. Haug, A. Haesler, Sanchez, PDA, Wark, D., Y. Ramachers, Vorobyev, A, K. Nikolics, Sterian AR, L.F. Thompson, Crivelli, P, Ratoff PN, BERARDI, Vincenzo, Vasseur, G., Gavrilov G, Alekou, A., A. Izmaylov, Mursula, K, Sato, F., Dawson, J., K. Nguyen, Nesterenko, D.A., Barker, Gary John, Viant T, Ioannisian, A.N., Maalampi, J, Kosyanenko S, Stahl, A., Saftoiu A, P. Gorodetzky, Bartmann, W., Pascoli S, Weber, M, A. Blondel, Martin-Mari, C., Pascoli, S., Sterian, AR, Bay, F., Agostino, L, Khotjantsev A, Kreslo, I., Chipesiu, F., P.N. Ratoff, Pistillo, C., Weber, A, Ballett, P, Wu S, Papaphilippou, Y., Ristea O, Kryn, D., Bésida O, S. Wu, Davenne, T, Narita, S, Mazzucato, E., Shaposhnikova E, Vincke H, M. Calviani, V. Suvorov, Jipa, A, Robert A, Pectu, M, De Jong, J., Boyd, Steve B., Nguyen, Khoi N., A. Mirizzi, Ioannisian A, Vincke, H., Enqvist, T., Resnati, F., Mercadante, A, A. Robert, Ioannisian AN, Mirizzi, A, Cata-Danil G, Levy, J-M, Kormos L, Erykalov A, Periale L, Blebea-Apostu, A.M., Déclais Y, Ariga, A., Shaposhnikova, E, Suhonen J, Banerjee D, Asfandiyarov, R, Cantini C, Papaphilippou Y, M. Pectu, Esanu T, Finch AJ, T. Kalliokoski, Gomez, J.J., Zalipska, J, Tsenov, R., D. Franco, Nguyen K, Robert, A, Hasegawa, T., Angus D, Jipa A, Narita S, Bravar, A, Sanchez, P. del Amo, Hierholzer, Martin, Weber, Michael, Pistillo, Ciro, Haug, Sigve, Ariga, Akitaka, Strauss, Thomas, Ereditato, Antonio, Kawada, Jiro, Kreslo, Igor, Ariga, Tomoko, Sanchez, P Del Amo, Novikov, Yu   +983 more
core   +2 more sources

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source