Results 91 to 100 of about 228,598 (287)

ELFENN: A Generalized Platform for Modeling Ephaptic Coupling in Spiking Neuron Models

Frontiers in Neuroinformatics, 2019
The transmembrane ionic currents that underlie changes in a cell's membrane potential give rise to electric fields in the extracellular space. In the context of brain activity, these electric fields form the basis for extracellularly recorded signals ...
Aaron R. Shifman, Aaron R. Shifman, Aaron R. Shifman, John E. Lewis, John E. Lewis, John E. Lewis   +5 more
doaj   +1 more source

Reversibly Migratable Fluorescent Probe for Precise and Dynamic Evaluation of Cell Mitochondrial Membrane Potentials. [PDF]

Biosensors (Basel), 2022
Song G, He H, Chen W, Lv Y, Chu PK, Wang H, Li P.   +6 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators. [PDF]

Commun Biol, 2021
Rühl P, Langner JM, Reidel J, Schönherr R, Hoshi T, Heinemann SH.   +5 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Kv11 (ether-à-go-go-related gene) voltage-dependent K⁺ channels promote resonance and oscillation of subthreshold membrane potentials. [PDF]

J Physiol, 2021
Matsuoka T, Yamasaki M, Abe M, Matsuda Y, Morino H, Kawakami H, Sakimura K, Watanabe M, Hashimoto K.   +8 more
europepmc   +1 more source

Origin of the membrane potential in plasmodial droplets of Physarum polycephalum. Evidence for an electrogenic pump. [PDF]

, 1981
H. Kuroda, Reiko Kuroda
openalex   +1 more source

Prostate Cancer Secretome and Membrane Proteome from Pten Conditional Knockout Mice Identify Potential Biomarkers for Disease Progression [PDF]

, 2022
Nilton José dos Santos, Ana Carolina Lima Camargo, Hernandes F. Carvalho, Luís Antônio Justulin, Sérgio Luís Felisbino   +4 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source