Results 101 to 110 of about 1,708,376 (302)

Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules

Frontiers in Physiology, 2019
T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and signaling proteins, thereby supporting excitation–contraction coupling. T-tubules are often remodeled in heart failure.
Sarah Helena Vermij, Hugues Abriel, Jan Pavel Kucera   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Sensing membrane curvature [PDF]

, 2003
Transport vesicle formation and fusion are highly regulated processes that require the sequential assembly and disassembly of proteinacious membrane coats.
Burger, Koert N.J, Burger, K.N.J., Imaging, Holthuis, Joost C.M, Membraan enzymologie, Holthuis, J.C.M., Dep Biologie, Membrane Enzymlogy 2, Dep Scheikunde   +8 more
core   +2 more sources

Relationship Between Some Parameters of the Membrane-Redox Potentials Three-State Line System with the Human Constitutional Types of Traditional Medicine

Central Asian Journal of Medical Sciences, 2015
Objectives: According to Tibetan-Mongolian traditional medicine theory, humans are classified into three main individuals based on the Rlung, Mkhris or Badgan symbolic code (SC).
Narantsetseg Badarch, Ambaga Miyegombo, Khishigjargal Ser-Od, Sarantsetseg Bandi   +3 more
doaj   +1 more source

The membrane dipole potential in a total membrane potential model. Applications to hydrophobic ion interactions with membranes

Biophysical Journal, 1986
The total potential energy profile for hydrophobic ion interactions with lipid bilayers can be written as the sum of four terms: the electrical Born, image and dipole contributions, and a neutral energy term. We introduce a specific model for the membrane dipole potential, treating it as a two-dimensional array of point dipoles located near each ...
Flewelling, R.F., Hubbell, W.L.
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Flow-field mitigation of membrane fouling (FMMF) via manipulation of the convective flow in cross-flow membrane applications

, 2016
Membrane fouling by particulates is largely driven by permeate drag that causes the foulants to move towards the membrane. Cross-flow is used to induce shear at the membrane surface to mitigate the fouling.
Fane, Anthony Gordon, Akhondi, Ebrahim, Krantz, William Bill, Tanudjaja, Henry Jonathan, Zamani, Farhad, Chew, Jia Wei   +5 more
core   +1 more source

Furan fatty acids efficiently rescue brain cells from cell death induced by oxidative stress [PDF]

, 2013
Treatment of rat brain C6 astroglioma cells with furan fatty acid F6 prior to exposure to hydrogen peroxide shows a strong protective effect of F6 against cell death resulting from oxidative stress.
Cox, R.C., Teixeira, A., Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics, Sub Membrane Enzymology begr. 01-06-12, Egmond, M.R., Membrane Enzymology   +6 more
core   +1 more source

Photolipid excitation triggers depolarizing optocapacitive currents and action potentials

Nature Communications
Optically-induced changes in membrane capacitance may regulate neuronal activity without requiring genetic modifications. Previously, they mainly relied on sudden temperature jumps due to light absorption by membrane-associated nanomaterials or water ...
Carlos A. Z. Bassetto, Juergen Pfeffermann, Rohit Yadav, Simon Strassgschwandtner, Toma Glasnov, Francisco Bezanilla, Peter Pohl   +6 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source