Results 91 to 100 of about 220,443 (295)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Relationship Between Some Parameters of the Membrane-Redox Potentials Three-State Line System with the Human Constitutional Types of Traditional Medicine

open access: yesCentral Asian Journal of Medical Sciences, 2015
Objectives: According to Tibetan-Mongolian traditional medicine theory, humans are classified into three main individuals based on the Rlung, Mkhris or Badgan symbolic code (SC).
Narantsetseg Badarch   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Studies on the membrane potentials of some imperfect clay and shale membranes

open access: yes, 1950
The membrane potentials of three imperfect shale membranes were measured for a number of electrolytes. The transference numbers of ions within the membranes were determined in an apparatus which is described.
Williams, Sherrod Ambrose
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Correlations of the free membrane potentials of stimulated MSNs in the striatum network.

open access: yes, 2013
(A) Example of the free membrane potential traces of two stimulated MSNs without any input correlation ( = 0,  = 0). As there was no correlation, neither within nor between the inputs to the two MSNs, the free membrane potentials did not show any ...
Man Yi Yim (339030)   +2 more
core   +1 more source

Shengmaisan Regulates Pacemaker Potentials in Interstitial Cells of Cajal in Mice

open access: yesJournal of Pharmacopuncture, 2013
Objectives: Shengmaisan (SMS) is a traditional Chinese medicine prescription widely used for the treatment of diverse organs in Korea. The interstitial cells of Cajal (ICCs) are pacemaker cells that play an important role in the generation of coordinated
Kim Byung Joo
doaj   +1 more source

Determining K+ channel activation curves from K+ channel currents often requires the Goldman-Hodgkin-Katz equation

open access: yesFrontiers in Cellular Neuroscience, 2009
Potassium ion current in nerve membrane, IK, has traditionally been described by IK = gK(V-EK), where gK is the K ion conductance, V is membrane potential, and EK is the K+ Nernst potential. This description has been unchallenged by most investigators in
john r Clay
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Effects of calcium deficiency on cell membrane potentials of isolated frog hearts

open access: yes, 1960
Membrane potentials were recorded in isolated frog hearts. Observations were made on the effects of calcium deficiency upon resting potential, action potential, overshoot, maximum depolarization rate and action potential contour.
F. Ware, A. L. Bennett, A. R. McIntyre
core   +1 more source

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