Results 101 to 110 of about 12,112,951 (393)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

"Water-free" computer model for fluid bilayer membranes

open access: yes, 2003
We use a simple and efficient computer model to investigate the physical properties of bilayer membranes. The amphiphilic molecules are modeled as short rigid trimers with finite range pair interactions between them.
Helfrich W., Oded Farago
core   +1 more source

Donnan Membrane Potential [PDF]

open access: yesNature, 1944
IN a recent communication in NATURE (July 17, 1943, p. 76) I applied the Boltzmann distribution law to the Donnan membrane equilibrium between two compartments, compartment (1) containing colloidal (or non-diffusible) ions plus diffusible ions, compartment (2) containing only diffusible ions. From the equations obtained, it follows that at the same pH.
openaire   +2 more sources

Fluorinated Membrane Potential Probes [PDF]

open access: yesBiophysical Journal, 2011
To explore the effect of fluorination on photophysical properties of membrane potential probes, we developed synthetic methods for ANEP dyes with fluorine substitutions at the donor, bridge, and acceptor sides. Fluorination on acceptor side induces red shifts in optical spectra while on donor side it induces blue shifts.
Adrian Negrean   +3 more
openaire   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules

open access: yesFrontiers in Physiology, 2019
T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and signaling proteins, thereby supporting excitation–contraction coupling. T-tubules are often remodeled in heart failure.
Sarah Helena Vermij   +2 more
doaj   +1 more source

Measurements of membrane potentials in plant mitochondria with the safranine method.

open access: yesPlant Physiology, 1982
The positively charged dye, safranine, has been used as an indicator of membrane potentials in mung bean (Phaseolus aureus) and Voodoo lily (Sauromatum guttatum) mitochondria under a variety of metabolic conditions. The spectral response of safranine has
A. Moore, W. Bonner
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Relationship Between Some Parameters of the Membrane-Redox Potentials Three-State Line System with the Human Constitutional Types of Traditional Medicine

open access: yesCentral Asian Journal of Medical Sciences, 2015
Objectives: According to Tibetan-Mongolian traditional medicine theory, humans are classified into three main individuals based on the Rlung, Mkhris or Badgan symbolic code (SC).
Narantsetseg Badarch   +3 more
doaj   +1 more source

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation

open access: yesNeural Regeneration Research, 2020
Transient receptor potential melastatin 2 (TRPM2) is an important ion channel that represents a potential target for treating injury caused by cerebral ischemia.
Tao Pan   +7 more
doaj   +1 more source

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