Results 171 to 180 of about 12,231,174 (337)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Calcium-Mediated Oscillation in Membrane Potentials and Atrial-Triggered Activity in Atrial Cells of Casq2^R33Q/R33Q Mutation Mice. [PDF]

Front Physiol, 2018
Zhang JC, Wu HL, Chen Q, Xie XT, Zou T, Zhu C, Dong Y, Xiang GJ, Ye L, Li Y, Zhu PL.   +10 more
europepmc   +1 more source

A Computer Evaluation of Equations for Predicting the Potential across Biological Membranes

, 1969
Steven A. Rosenberg
openalex   +1 more source

The Effects of Zinc on Contractility, Membrane Potentials, and Cation Content of Rat Atria [PDF]

, 1965
Frank R. Ciofalo, Lyell J. Thomas
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Statistically derived asymmetric membrane potentials from α-helical and β-barrel membrane proteins. [PDF]

Sci Rep, 2018
Koehler Leman J, Bonneau R, Ulmschneider MB.   +2 more
europepmc   +1 more source

Interactions of Calcium with Sodium and Potassium in Membrane Potentials of the Lobster Giant Axon [PDF]

, 1960
William J. Adelman, John Call Dalton
openalex   +1 more source

Estimation of membrane potentials of individual lymphocytes by flow cytometry.

Proceedings of the National Academy of Sciences of the United States of America, 1979
H. Shapiro, P. Natale, L. Kamentsky
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Calcium-mediated DAD in membrane potentials and triggered activity in atrial myocytes of ETV1^{f / f}MyHC^{Cre /+} mice. [PDF]

J Cell Mol Med
Fang LH, Chen Q, Cheng XL, Li XQ, Zou T, Chen JQ, Xiang GJ, Xue Q, Li Y, Zhang JC.   +9 more
europepmc   +1 more source