Results 151 to 160 of about 1,708,376 (302)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Piezoelectric reverse osmosis (RO) membrane: fabrication and anti-fouling effect
In this study, a novel piezoelectric RO membrane with vibrating mechanism when exposed to an electric field was developed. The vibration due to the piezoelectric effect can disturb the concentration polarization layer on the membrane surface and minimize
Fu, Jia Shen +3 more
core +1 more source
Mitochondrial membrane potential and aging
Aging Cell, 2003 SummaryThe mitochondrial membrane potential (or protonmotive force) is the central bioenergetic parameter that controls respiratory rate, ATP synthesis and the generation of reactive oxygen species, and is itself controlled by electron transport and proton leaks.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2018 A highly-efficient zeolitic imidazolate framework-8 (ZIF-8) embedded polydimethylsiloxane (PDMS) mixed matrix membrane (MMM) supported by a polyvinylidene fluoride (PVDF) nanofibrous substrate was developed for phenol removal in an aqueous-aqueous ...
Tan, Choon-Hong +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials. [PDF]
Methods Cell Biol, 2020 Wolf DM, Segawa M, Shirihai OS, Liesa M.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Towards novel antibacterial development: from peptidoglycan to lipoprotein biogenesis [PDF]
, 2016 Antibiotic resistance has been an emerging threat to the public health. Since the discovery of penicillin reported in 1929, continuous effort has been made in the past decades to discover more effective antibacterial molecules through drug-target ...
Sub Membrane Biochemistry & Biophysics +2 more
core
Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials. [PDF]
Bioelectricity, 2020 Kamaldinov T +4 more
europepmc +1 more source