Results 141 to 150 of about 1,708,376 (302)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Multitask learning of a biophysically-detailed neuron model.
PLoS Computational BiologyThe human brain operates at multiple levels, from molecules to circuits, and understanding these complex processes requires integrated research efforts.
Jonas Verhellen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2015 The fabrication of new membrane that is able to produce stable high power density is essential for the development of pressure retarded osmosis (PRO) technology.
Li, Ye +7 more
core +1 more source
Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels.
PLoS BiologyFast skeletal muscle fibers from zebrafish share a number of functional properties with mammalian twitch muscle fibers, making this vertebrate a precious model to investigate the pathophysiology of neuromuscular disorders.
Léa Demesmay +10 more
doaj +1 more source
Impaired thalamic burst firing in fragile X syndrome
Cell ReportsSummary: The thalamus performs a critical role in sensory processing by gating the flow of sensory information to the neocortex and directing sensory-guided behaviors, functions that are disrupted in people with autism spectrum disorder (ASD).
Ronan T. O’Shea +2 more
doaj +1 more source
Measuring mitochondrial membrane potential
The EMBO JournalMitochondrial function determines the balance between health and disease, making understanding their bioenergetics an increasingly important focus across biomedical research. Among the most relevant and accessible measures of mitochondrial function in intact cells is the mitochondrial membrane potential (ΔΨm), typically determined with commercially ...
Oscar Tovar-Ferrero +4 more
openaire +3 more sources